5-(((3,5-bis(trifluoromethyl)benzyl)(5-bromopyrimidin-2-yl)amino)methyl)-N,N-bis(cyclopropylmethyl)-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-amine | 920493-89-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-(((3,5-bis(trifluoromethyl)benzyl)(5-bromopyrimidin-2-yl)amino)methyl)-N,N-bis(cyclopropylmethyl)-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-amine
• 英文别名: 5-[[[3,5-bis(trifluoromethyl)phenyl]methyl-(5-bromopyrimidin-2-yl)amino]methyl]-N,N-bis(cyclopropylmethyl)-1,3-dimethylpyrazolo[3,4-b]pyridin-6-amine
• CAS: 920493-89-6
• 化学式: C₃₀H₃₀BrF₆N₇
• 分子量: 682.51
• InChiKey: KXHBUSUCVWEJQV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  44
• 可旋转键数：
  10
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  63
• 氢给体数：
  0
• 氢受体数：
  12

文献信息

• [EN] 5 - BENZYLAMINOMETHYL - 6 - AMINOPYRAZOLO [3, 4 -B] PYRIDINE DERIVATIVES AS CHOLESTERYL ESTER -TRANSFER PROTEIN (CETP) INHIBITORS USEFUL FOR THE TREATMENT OF ATHEROSCLEROSIS<br/>[FR] DÉRIVÉS DE 5 - BENZYLAMINOMÉTHYL - 6 - AMINOPYRAZOLO [3, 4 -B] PYRIDINE UTILES COMME INHIBITEURS DE LA CHOLESTÉRYL ESTER -TRANSFER PROTÉINE (CETP) DANS LE TRAITEMENT DE L'ATHÉROSCLÉROSE
  申请人：REDDYS LAB LTD DR

  公开号：WO2013046045A1

  公开（公告）日：2013-04-04

  The present application relates to a series of substituted pyra- zolopyridin-6-amines having the general formula (I), including their stereoisomers and/or their pharmaceutically acceptable salts. Wherein R, R1, R2, Ra, Raa, Rb and n are as defined herein. The present invention further relates to pharmaceutical compositions comprising compounds of formula (I). The compounds of this application are useful as CETP inhibitors for increasing HDL cholesterol and decreasing LDL cholesterol in a patient.

  本申请涉及一系列取代吡嗪吡啶-6-胺化合物，其具有通式（I），包括它们的立体异构体和/或其药用可接受的盐。其中R、R1、R2、Ra、Raa、Rb和n如本文所定义。本发明还涉及包含通式（I）化合物的药物组合物。本申请中的化合物可用作CETP抑制剂，用于增加患者的HDL胆固醇并降低LDL胆固醇。
• Novel benzylamine derivatives and their utility as cholesterol ester-transfer protein inhibitors
  申请人：Baruah Anima

  公开号：US20070015758A1

  公开（公告）日：2007-01-18

  The present invention provides, among other things, new benzylamine compounds, compositions comprising benzylamine compounds, methods of making benzylamine compounds, and methods of using benzylamine compounds for treating or preventing a variety of conditions or diseases associated with lipoprotein metabolism.

  本发明提供了新的苄基胺化合物，包括苄基胺化合物的组合物，制备苄基胺化合物的方法，以及使用苄基胺化合物治疗或预防与脂蛋白代谢有关的各种疾病或症状的方法。
• 5 - BENZYLAMINOMETHYL - 6 - AMINOPYRAZOLO [3, 4 -B] PYRIDINE DERIVATIVES AS CHOLESTERYL ESTER-TRANSFER PROTEIN (CETP) INHIBITORS USEFUL FOR THE TREATMENT OF ATHEROSCLEROSIS
  申请人：DR. REDDY'S LABORATORIES, LTD.

  公开号：US20140288072A1

  公开（公告）日：2014-09-25

  The present application relates to a series of substituted pyra-zolopyridin-6-amines having the general formula (I), including their stereoisomers and/or their pharmaceutically acceptable salts. Wherein R, R 1 , R 2 , R a , R aa , R b and n are as defined herein. The present invention further relates to pharmaceutical compositions comprising compounds of formula (I). The compounds of this application are useful as CETP inhibitors for increasing HDL cholesterol and decreasing LDL cholesterol in a patient.

  本申请涉及一系列取代的吡唑吡啶-6-胺衍生物，其具有通式（I），包括其立体异构体和/或其药学上可接受的盐。其中R，R1，R2，Ra，Raa，Rb和n的定义如本文所述。本发明还涉及包含式（I）化合物的制药组合物。本申请的化合物可用作CETP抑制剂，以增加患者的高密度脂蛋白胆固醇并降低低密度脂蛋白胆固醇。
• NOVEL BENZYLAMINE DERIVATIVES AND THEIR UTILITY AS CHOLESTEROL ESTER-TRANSFER PROTEIN INHIBITORS
  申请人：DR. REDDY'S LABORATORIES LTD.

  公开号：US20140134235A1

  公开（公告）日：2014-05-15

  The present invention provides, among other things, new benzylamine compounds, compositions comprising benzylamine compounds, methods of making benzylamine compounds, and methods of using benzylamine compounds for treating or preventing a variety of conditions or diseases associated with lipoprotein metabolism.

  本发明提供了新的苄基胺化合物，包括苄基胺化合物的组合物，制备苄基胺化合物的方法，以及使用苄基胺化合物治疗或预防与脂蛋白代谢有关的各种疾病或症状的方法。
• SELECTIVE BENZYLAMINE DERIVATIVES AND THEIR UTILITY AS CHOLESTEROL ESTER-TRANSFER PROTEIN INHIBITORS
  申请人：Dr. Reddy's Laboratories Ltd.

  公开号：EP1981342B1

  公开（公告）日：2016-11-30