tert-Butyl-[2,6-dimethyl-4-(2-methyl-allyl)-phenoxy]-dimethyl-silane | 118630-98-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tert-Butyl-[2,6-dimethyl-4-(2-methyl-allyl)-phenoxy]-dimethyl-silane
• CAS: 118630-98-1
• 化学式: C₁₈H₃₀OSi
• 分子量: 290.521
• InChiKey: YAUWIQFEMSMZCY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.81
• 重原子数：
  20.0
• 可旋转键数：
  4.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  9.23
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  tert-Butyl-[2,6-dimethyl-4-(2-methyl-allyl)-phenoxy]-dimethyl-silane 在 sodium hydroxide 、 硼烷四氢呋喃络合物 、 四溴化碳 、 双氧水 、 三苯基膦 作用下， 以 乙醚 为溶剂， 反应 7.42h， 生成 (+/-)-4-(3-Bromo-2-methylpropyl)-1-<(tert-butyldimethylsilyl)oxy>-2,6-dimethylbenzene
  参考文献：
  名称：

  Formation of Carbon-Carbon Bonds via Quinone Methide-Initiated Cyclization Reactions

  摘要：

  p-Quinone methides were found to be excellent electrophilic cyclization initiators for the formation of six-membered rings. Cyclizations to form five- and seven-membered rings were also studied. Oxidation of 2,6-disubstituted phenols with Ag2O afforded the corresponding quinone methides. A wide range of cyclization terminators/nucleophiles were found to be effective in the cyclizations, including: allylsilane, beta-keto esters, furan, pyrrole, indole, and a number of alkenes. The yields of the cyclizations were generally high.

  DOI：

  10.1021/jo00100a039
• 作为产物：
  描述：

  2,6-Dimethyl-4-(2-methylpropenyl)phenol 、 叔丁基二甲基氯硅烷 在 咪唑 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 生成 tert-Butyl-[2,6-dimethyl-4-(2-methyl-allyl)-phenoxy]-dimethyl-silane
  参考文献：
  名称：

  Formation of Carbon-Carbon Bonds via Quinone Methide-Initiated Cyclization Reactions

  摘要：

  p-Quinone methides were found to be excellent electrophilic cyclization initiators for the formation of six-membered rings. Cyclizations to form five- and seven-membered rings were also studied. Oxidation of 2,6-disubstituted phenols with Ag2O afforded the corresponding quinone methides. A wide range of cyclization terminators/nucleophiles were found to be effective in the cyclizations, including: allylsilane, beta-keto esters, furan, pyrrole, indole, and a number of alkenes. The yields of the cyclizations were generally high.

  DOI：

  10.1021/jo00100a039