12-[3,6-Difluoro-3,4,6-trideoxy-β-D-allopyranosyl]-2,3,9,10-tetrafluoro-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione | 463303-33-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 12-[3,6-Difluoro-3,4,6-trideoxy-β-D-allopyranosyl]-2,3,9,10-tetrafluoro-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
• 英文别名: 6,7,19,20-tetrafluoro-3-[(2R,3S,4R,6S)-4-fluoro-6-(fluoromethyl)-3-hydroxyoxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4,6,8,10,15,17,19,21-nonaene-12,14-dione
• CAS: 463303-33-5
• 化学式: C₂₆H₁₅F₆N₃O₄
• 分子量: 547.413
• InChiKey: FMWLJAQQAZHHED-CMOMNYIYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  39
• 可旋转键数：
  2
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  96.4
• 氢给体数：
  3
• 氢受体数：
  10

文献信息

• Topoisomerase I selective cytotoxic sugar derivatives of indolopyrrolocarbazoles
  申请人：——

  公开号：US20030083271A1

  公开（公告）日：2003-05-01

  The present invention relates to fluoro sugar and other sugar derivatives of indolopyrrolocarbazoles, their salts and hydrates, which exhibit selective topoisomerase I (topo I) activity, are useful in inhibiting the proliferation of tumor cells and exhibit an antitumor effect, as well as processes for their preparation.

  本发明涉及氟糖和其他印度洋红咔唑衍生物的糖衍生物，其盐和水合物具有选择性拓扑异构酶I（topo I）活性，对抑制肿瘤细胞增殖和表现出抗肿瘤效果有用，以及它们的制备过程。
• [EN] TOPOISOMERASE I SELECTIVE CYTOTOXIC SUGAR DERIVATIVES OF INDOLOPYRROLOCARBAZOLES<br/>[FR] DERIVES D'INDOLOPYRROLOCARBAZOLES SUCRESCYTOTOXIQUES SELECTIVEMENT CONTRE LA TOPOISOMERASE I
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2002077255A1

  公开（公告）日：2002-10-03

  The present invention relates to fluoro sugar and other sugar derivatives of indolopyrrolocarbazoles, their salts and hydrates, which exhibit selective topoisomerase I (topo I) activity, are useful in inhibiting the proliferation of tumor cells and exhibit an antitumor effect, as well as processes for their preparation.

  本发明涉及氟代糖和其他吲哚吡咯嘧啶衍生物的糖衍生物，其盐和水合物具有选择性拓扑异构酶I（topo I）活性，对抑制肿瘤细胞增殖具有用处并表现出抗肿瘤效果，以及它们的制备过程。
• TOPOISOMERASE I SELECTIVE CYTOTOXIC SUGAR DERIVATIVES OF INDOLOPYRROLOCARBAZOLES
  申请人：Bristol-Myers Squibb Company

  公开号：EP1370673A1

  公开（公告）日：2003-12-17
• EP1370673A4
  申请人：——

  公开号：EP1370673A4

  公开（公告）日：2006-08-09