2-acetyl-N,5-diphenylpenta-2,4-dienamide | 77720-42-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-acetyl-N,5-diphenylpenta-2,4-dienamide
• CAS: 77720-42-4
• 化学式: C₁₉H₁₇NO₂
• 分子量: 291.349
• InChiKey: YRVNBXLBTGKMFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.85
• 重原子数：
  22.0
• 可旋转键数：
  5.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  46.17
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  2-acetyl-N,5-diphenylpenta-2,4-dienamide 以 5,5-dimethyl-1,3-cyclohexadiene 为溶剂， 以91%的产率得到5-(1-hydroxyethylidene)-1,2-diphenyl-2H-pyridin-6-one
  参考文献：
  名称：

  Hydrogen Bond-Assisted 6π-Azaelectrocyclization of Penta-2,4-dienamides: Synthesis of Dihydropyridin-2(3H)-ones

  摘要：

  A facile and efficient synthesis of substituted dihydropyridin-2(3H)-ones is developed from penta-2,4-dienamides, in which an intramolecular C-N bond was formed through thermal 6 pi-azaelectrocyclization. The intra-molecular hydrogen bonding-assisted cyclization reaction opens access to a variety of dihydropyridin-2(3H)-ones.

  DOI：

  10.1021/jo4001959
• 作为产物：
  描述：

  N-乙酰乙酰苯胺 、 肉桂醛 在 哌啶 作用下， 以 乙醇 为溶剂， 反应 3.5h， 生成 2-acetyl-N,5-diphenylpenta-2,4-dienamide
  参考文献：
  名称：

  Facile and efficient synthesis of quinolin-2(1H)-ones via cyclization of penta-2,4-dienamides mediated by H2SO4

  摘要：

  通过浓硫酸（98%）介导的五-2,4-二烯酰胺的分子内环化反应，开发了一种简便且高效的取代喹啉-2(1H)-酮合成方法，并提出了一种涉及双阳离子超级亲电试剂形成和随后的分子内亲核环化反应的机制。

  DOI：

  10.1039/c2ob25767j

文献信息

• Synthesis, structural characterization and biological studies of copper complexes with 2-aminobenzothiazole derivatives
  作者：J. Joseph、G. Boomadevi Janaki

  DOI：10.1016/j.molstruc.2014.01.028

  日期：2014.4

  Novel copper complexes of 2-aminobenzothiazole derivatives were synthesized by the condensation of Knoevenagel condensate acetoacetanilide (obtained from substituted benzaldehydes and acetoacetanilide) and 2-aminobenzothiazole. They were thoroughly characterized by elemental analysis, IR, H-1 NMR, UV-Vis., MS Spectra, molar conductance, magnetic moment and electrochemical studies. These spectral studies suggested that distorted square planar geometry for all the complexes. Molar conductance data and magnetic susceptibility measurements provide evidence for monomeric and neutral nature of the complexes. The electrochemical behaviour of the ligand and complexes in DMSO at 298 K was studied. The present ligand systems stabilize the unusual oxidation states of copper ion during electrolysis. Antibacterial screening of the ligands and their complexes reveal that all the complexes show higher activities than the free ligands. (C) 2014 Elsevier B.V. All rights reserved.
• Khali, Zarif A.; Yanni, Amal S., Journal of the Indian Chemical Society, 1981, vol. 58, p. 168 - 170
  作者：Khali, Zarif A.、Yanni, Amal S.

  DOI：——

  日期：——
• Khalil, Zarif H.; Yanni, Amal S., Journal of the Indian Chemical Society, 1981, vol. 58, p. 494 - 497
  作者：Khalil, Zarif H.、Yanni, Amal S.

  DOI：——

  日期：——
• Raman; Joseph, Polish Journal of Chemistry, 2007, vol. 81, # 7, p. 1303 - 1311
  作者：Raman、Joseph

  DOI：——

  日期：——