2-{(5E)-2-[(dimethylamino)carbonyl]-6-methoxy-1-methyl-4-oxo-5-hexenylidene}-1-hydrazinecarboxamide | 1027008-25-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-{(5E)-2-[(dimethylamino)carbonyl]-6-methoxy-1-methyl-4-oxo-5-hexenylidene}-1-hydrazinecarboxamide
• CAS: 1027008-25-8
• 化学式: C₁₂H₂₀N₄O₄
• 分子量: 284.315
• InChiKey: ZBZYAFOZRYEBBR-BXEJXYHESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.15
• 重原子数：
  20.0
• 可旋转键数：
  7.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  114.09
• 氢给体数：
  2.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  2-{(5E)-2-[(dimethylamino)carbonyl]-6-methoxy-1-methyl-4-oxo-5-hexenylidene}-1-hydrazinecarboxamide 在 Amberlyst 15 作用下， 以 四氢呋喃 为溶剂， 以66%的产率得到3-{2-[(dimethylamino)carbonyl]-3-oxobutyl}-1H-1-pyrazolecarboxamide
  参考文献：
  名称：

  Flexible Protocol for the Chemo- and Regioselective Building of Pyrroles and Pyrazoles by Reactions of Danishefsky’s Dienes with 1,2-Diaza-1,3-butadienes

  摘要：

  The versatility of the Mukaiyama-Michael-type addition/heterocyclization of Danishefsky's diene with 1,2-diaza-1,3-butadienes was applied to the synthesis of both 4H-1-aminopyrroles and 4,5H-pyrazoles. Thus, the same reagents furnished different types of highly functionalized azaheterocycles essentially depending on their structure: as a matter of fact, R-1 = COOR or CONR2 differently affects the acidity of the proton at the adjacent carbon. An unexpected formation of 5H-1-aminopyrroles from the reactions carried out in water was also observed.

  DOI：

  10.1021/ol800557h
• 作为产物：
  描述：

  2-[3-(dimethylamino)-1-ethyl-3-oxoprop-1-en-1-yl]diazenecarboxamide 、 反-1-甲氧基-3-(三甲基硅氧基)-1,3-丁二烯 在 zinc(II) chloride 、 四丁基氟化铵 作用下， 以 二氯甲烷 、 四氢呋喃 为溶剂， 以90%的产率得到2-{(5E)-2-[(dimethylamino)carbonyl]-6-methoxy-1-methyl-4-oxo-5-hexenylidene}-1-hydrazinecarboxamide
  参考文献：
  名称：

  Flexible Protocol for the Chemo- and Regioselective Building of Pyrroles and Pyrazoles by Reactions of Danishefsky’s Dienes with 1,2-Diaza-1,3-butadienes

  摘要：

  The versatility of the Mukaiyama-Michael-type addition/heterocyclization of Danishefsky's diene with 1,2-diaza-1,3-butadienes was applied to the synthesis of both 4H-1-aminopyrroles and 4,5H-pyrazoles. Thus, the same reagents furnished different types of highly functionalized azaheterocycles essentially depending on their structure: as a matter of fact, R-1 = COOR or CONR2 differently affects the acidity of the proton at the adjacent carbon. An unexpected formation of 5H-1-aminopyrroles from the reactions carried out in water was also observed.

  DOI：

  10.1021/ol800557h