4-amino-2-cyclopropyl-5-pyrimidinecarboxaldehyde | 76574-38-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-amino-2-cyclopropyl-5-pyrimidinecarboxaldehyde
• 英文别名: 2-cyclopropyl-4-amino-5-pyrimidinecarbaldehyde；4-Amino-2-cyclopropylpyrimidine-5-carbaldehyde
• CAS: 76574-38-4
• 化学式: C₈H₉N₃O
• 分子量: 163.179
• InChiKey: LSVNGXSYGCNBIM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  68.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-amino-2-cyclopropyl-5-pyrimidinecarboxaldehyde 、 邻甲基苯乙腈 在 sodium ethanolate 作用下， 以 乙醇 为溶剂， 反应 3.0h， 以43%的产率得到2-Cyclopropyl-6-o-tolyl-pyrido[2,3-d]pyrimidin-7-ylamine
  参考文献：
  名称：

  Antihypertensive activity of 6-arylpyrido[2,3-d]pyrimidin-7-amine derivatives

  摘要：

  A series of 51 6-arylpyrido[2,3-d]pyrimidin-7-amine derivatives was prepared and evaluated for antihypertensive activity in the conscious spontaneously hypertensive rat. A number of these compounds, notably 6-(2,6-dichlorophenyl)-2-methylpyrido[2,3-d]pyrimidin-7-amine (36), lowered blood pressure in these rats in a gradual and sustained manner to normotensive levels at oral doses of 10-50 mg/kg. Normalized blood pressure levels could then be maintained by single daily oral doses. The effect of structural variation in the 6-aryl group and in the 2 and 4 positions of the pyridopyrimidine ring on activity is reported and discussed.

  DOI：

  10.1021/jm00136a006
• 作为产物：
  描述：

  4-氨基-2-乙基-5-嘧啶甲腈 在 镍 甲酸 、 氢气 作用下， 反应 3.0h， 以49%的产率得到4-amino-2-cyclopropyl-5-pyrimidinecarboxaldehyde
  参考文献：
  名称：

  Antihypertensive activity of 6-arylpyrido[2,3-d]pyrimidin-7-amine derivatives

  摘要：

  A series of 51 6-arylpyrido[2,3-d]pyrimidin-7-amine derivatives was prepared and evaluated for antihypertensive activity in the conscious spontaneously hypertensive rat. A number of these compounds, notably 6-(2,6-dichlorophenyl)-2-methylpyrido[2,3-d]pyrimidin-7-amine (36), lowered blood pressure in these rats in a gradual and sustained manner to normotensive levels at oral doses of 10-50 mg/kg. Normalized blood pressure levels could then be maintained by single daily oral doses. The effect of structural variation in the 6-aryl group and in the 2 and 4 positions of the pyridopyrimidine ring on activity is reported and discussed.

  DOI：

  10.1021/jm00136a006

文献信息

• CYCLIC AMINOMETHYL PYRIMIDINE DERIVATIVE
  申请人：SUMITOMO DAINIPPON PHARMA CO., LTD.

  公开号：US20160122319A1

  公开（公告）日：2016-05-05

  The present invention provides a cyclic aminomethyl pyrimidine derivative and a pharmaceutically acceptable salt thereof with high selectivity for dopamine D 4 receptors, which are useful for treating a disease such as attention deficit hyperactivity disorder. Specifically, a compound of formula (1) or a pharmaceutically acceptable salt thereof is provided, wherein n and m are independently 1 or 2; R a is C 1-6 alkyl group, C 3-6 cycloalkyl group, or amino group; R b is hydrogen atom, C 1-6 alkyl group or the like, provided that when R a is amino group, then R b is hydrogen atom; R c1 and R c2 are independently hydrogen atom, or C 1-6 alkyl group; R d1 and R d2 are independently hydrogen atom, fluorine atom or the like; ring Q is an optionally-substituted pyridyl group or an optionally-substituted isoquinolyl group; and the bond having a dashed line is a single or double bond.

  本发明提供了一种对多巴胺D4受体具有高选择性的环状氨基甲基嘧啶衍生物及其药用盐，可用于治疗注意力缺陷多动症等疾病。具体提供了一种公式(1)的化合物或其药用盐，其中n和m独立为1或2；Ra为C1-6烷基、C3-6环烷基或氨基；Rb为氢原子、C1-6烷基等，条件是当Ra为氨基时，Rb为氢原子；Rc1和Rc2独立为氢原子或C1-6烷基；Rd1和Rd2独立为氢原子、氟原子等；环Q为可选取代的吡啶基或可选取代的异喹啉基；且虚线表示的键为单键或双键。
• 丙酮酸脱氢酶系抑制剂类化合物及其制备方 法和应用
  申请人：华中师范大学

  公开号：CN109503496B

  公开（公告）日：2021-12-21

  本发明提供了一种丙酮酸脱氢酶系抑制剂类化合物及其制备方法和应用，特别是式I所示化合物或其立体异构体、几何异构体、互变异构体、消旋体、氮氧化物、水合物、溶剂化物、药学上可接受的盐，其中，R1和R2各自独立的选自氢、烷基、氨基或碳环基；R3为苯环任意位置上的单取代或多取代基，所述取代基可以相同或不同；X为酰腙基或腙基。该类化合物具有抑制丙酮酸脱氢酶的活性，能够预防和/或治疗植物疾病和抑制藻类生长
• US9732065B2
  申请人：——

  公开号：US9732065B2

  公开（公告）日：2017-08-15