cis-1,3-cyclohexanediacetic acid | 40098-81-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: cis-1,3-cyclohexanediacetic acid
• 英文别名: cis-(Cyclohexandiyl-1,3)-diessigsaeure, cis-(3-Carboxymethyl-cyclohexyl)-essigsaeure；(cis-cyclohexane-1,3-diyl)-di-acetic acid；(cis-Cyclohexan-1,3-diyl)-di-essigsaeure；2-[(1S,3R)-3-(carboxymethyl)cyclohexyl]acetic acid
• CAS: 40098-81-5
• 化学式: C₁₀H₁₆O₄
• 分子量: 200.235
• InChiKey: PFKKTUJMQOKZOR-OCAPTIKFSA-N

物化性质

• 沸点：
  413.0±18.0 °C(Predicted)
• 密度：
  1.171±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1,3-苯二乙酸 在 溶剂黄146 、 铂 作用下， 生成 cis-1,3-cyclohexanediacetic acid
  参考文献：
  名称：

  Theoretical foundations for sound's use in multimedia instruction to enhance learning

  摘要：

  Recent technological advances now snake possible the full integration of sound in instructional software. Sounds may gain and focus learner attention, reduce distracting stimuli, and make learning more engaging. In addition, they may help learners condense, elaborate on, and organize details, highlighting interconnections among new pieces of information and making connections to preexisting knowledge. Thus, sound may hold great promise for moderating acquisition, processing, and retrieval "noise" in instructional software. Unfortunately, interface and instructional design guides almost completely ignore sound, and research suggests many promising instructional uses remain largely unexplored. This paper explores information-processing and communication theoretical foundations for sound's systematic use in the instructional communication system and proposes a framework for a program of research on instructional software's use of sound.

  DOI：

  10.1007/bf02504912

文献信息

• [EN] SUBSTITUTED-QUINOXALINE-TYPE BRIDGED-PIPERIDINE COMPOUNDS AND THE USES THEREOF<br/>[FR] COMPOSÉS PIPÉRIDINE À LIAISON ET SUBSTITUÉS PAR UNE QUINOXALINE, ET LEURS UTILISATIONS
  申请人：PURDUE PHARMA LP

  公开号：WO2010010458A1

  公开（公告）日：2010-01-28

  The invention relates to Substituted-Quinoxaline-Type Bridged-Piperidine Compounds, compositions comprising an effective amount of a Substituted-Quinoxaline- Type Bridged-Piperidine Compound and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Substituted-Quinoxaline-Type Bridged-Piperidine Compound.

  这项发明涉及取代喹喔啉型桥式哌啶化合物，包括有效量的取代喹喔啉型桥式哌啶化合物的组合物，以及治疗或预防疼痛等疾病的方法，包括向需要治疗的动物施用有效量的取代喹喔啉型桥式哌啶化合物。
• The preparation and properties of neutral diamide ionophores for group IIA metal cations-II
  作者：Irving J. Borowitz、Josephine D. Readio、Ven-shun Li

  DOI：10.1016/s0040-4020(01)91239-6

  日期：1984.1

  cations as determined by Simon . (ETH Zurich) are reported. Selectivity ratios of over 100:1 for Na vs Ca were found for several piperidenyl amides of 1,2-phenylenedioxydiacetic acid. Incorporation of N-methylamino instead of ether oxygen groups into the basic structure gives a stronger cation binder which is still selective for Group IIA vs Group IA cations but with binding capacity for transition metal

  描述了一系列具有邻位醚和N，N-二烷基乙酰胺基的中性配体的制备。这些配体中的几个在其敏感的IIA组阳离子的甲醇中带有K app = 10 3 -10 5。据报道，通过Scatchard方法的结合常数对于许多主要与Ca，Sr，Mn和Ba的配体是一致的。二氯甲烷溶液中的配体通过其苦味酸盐从水中提取这些阳离子。电化学K ij锅当某些配体结合到液膜电极中并用西蒙（Simon）测定的各种阳离子测试时的（选择性）值。（ETH Zurich）。对于1,2-苯二氧基二乙酸的几种哌啶基酰胺，发现Na与Ca的选择性比超过100：1。将N-甲基氨基而不是醚氧基团结合到基本结构中会得到更强的阳离子结合剂，该结合剂对IIA族和IA族阳离子仍然具有选择性，但对过渡金属阳离子也具有结合能力。讨论了这些配体的Scatchard图的局限性以及电化学选择性与单一液相中阳离子结合顺序的不对应关系。
• Substituted-quinoxaline-type bridged-piperidine compounds and the uses thereof
  申请人：Purdue Pharma L.P.

  公开号：EP2537844A1

  公开（公告）日：2012-12-26

  The invention relates to Substituted-Quinoxaline-Type Bridged-Piperidine Compounds, compositions comprising an effective amount of a Substituted-Quinoxaline-Type Bridged-Piperidine Compound and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Substituted-Quinoxaline-Type Bridged-Piperidine Compound.

  本发明涉及取代喹喔啉型桥接哌啶化合物、包含有效量的取代喹喔啉型桥接哌啶化合物的组合物，以及治疗或预防疼痛等疾病的方法，包括向有需要的动物施用有效量的取代喹喔啉型桥接哌啶化合物。
• Westman et al., Journal of Organic Chemistry, 1963, vol. 28, p. 3512,3515
  作者：Westman et al.

  DOI：——

  日期：——
• Cavalleri et al., Farmaco, Edizione Scientifica, 1972, vol. 27, p. 829,831, 833, 838
  作者：Cavalleri et al.

  DOI：——

  日期：——