8-nonenoyl chloride | 102342-66-5

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 酰卤
• 英文名称: 8-nonenoyl chloride
• 英文别名: non-8-enoyl chloride
• CAS: 102342-66-5
• 化学式: C₉H₁₅ClO
• 分子量: 174.671
• InChiKey: FKEGHFZKKSLOCS-UHFFFAOYSA-N

物化性质

• 沸点：
  220.7±19.0 °C(Predicted)
• 密度：
  0.966±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  11
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  8-nonenoyl chloride 在 Grubbs catalyst first generation 作用下， 以 二氯甲烷 为溶剂， 生成 (10E,14Z)-14-Methyl-2-aza-bicyclo[16.3.1]docosa-1(22),10,14,18,20-pentaen-3-one
  参考文献：
  名称：

  A Versatile Approach toward the Ansamycin Antibiotics

  摘要：

  The ansamycin antibiotics contain metacyclophanic macrolactams, many of which possess potent antitumor activity. Only a few total syntheses of this family of natural products have been reported, and modifications to increase potency have not been described. Therefore, a method was developed to prepare the trienomycin A core via resin-bound triphenylphosphonium salts, which serve as both a reagent and a traceless linker to afford olefinic products that undergo ring-closing metathesis (RCM) to give macrocyclic scaffolds of varying ring sizes.

  DOI：

  10.1021/ol060022b
• 作为产物：
  描述：

  8-壬烯腈 在 氢氧化钾 、 草酰氯 作用下， 以 乙醇 、 水 、 苯 为溶剂， 反应 98.0h， 生成 8-nonenoyl chloride
  参考文献：
  名称：

  Chemistry of 1,3,5-tris(trimethylsiloxy)-1-methoxyhexa-1,3,5-triene, a .beta.-tricarbonyl trianion equivalent

  摘要：

  DOI：

  10.1021/jo00363a004

文献信息

• Reductive Alkylation of Amines with Carboxylic Ortho Esters
  作者：Renat Kadyrov、Konrad Moebus

  DOI：10.1002/adsc.202000510

  日期：2020.8.19

  carboxylic ortho esters could be used as an alkylating agent in the reductive alkylation of amines. A variety of amines, including amino acid esters, were alkylated affording mono‐alkylated products with high selectivity in practical to high yields using standard heterogeneous catalysts. By applying acyclic ortho esters alkylation was completed at room temperature.

  我们首次证明了羧酸原酸酯可以在胺的还原烷基化中用作烷基化剂。使用标准的多相催化剂，将多种胺（包括氨基酸酯）进行烷基化，从而以高产率实际可行地以高选择性生成单烷基化产物。通过施加无环原酸酯，在室温下完成烷基化。
• [EN] FLOUROALKYL, FLOUROALKOXY, PHENOXY, HETEROARYLOXY, ALKOXY, AND AMINE 1,4-BENZOQUINONE DERIVATIVES FOR TREATMENT OF OXIDATIVE STRESS DISORDERS<br/>[FR] DÉRIVÉS FLUOROALKYLE, FLUOROALCOXY, PHÉNOXY, HÉTÉROARYLOXY, ALCOXY, ET AMINE 1,4-BENZOQUINONE POUR LE TRAITEMENT DE TROUBLES DU STRESS OXYDATIF
  申请人：BIOELECTRON TECH CORP

  公开号：WO2017106803A1

  公开（公告）日：2017-06-22

  Disclosed herein are compounds and methods of using such compounds for treating or suppressing oxidative stress disorders, including mitochondrial disorders, impaired energy processing disorders, neurodegenerative diseases and diseases of aging, or for modulating one or more energy biomarkers, normalizing one or more energy biomarkers, or enhancing one or more energy biomarkers, wherein the compounds are tocopherol quinone derivatives. Further disclosed are compounds, compositions, and methods for treatment of, or prophylaxis against, radiation exposure.

  披露的是一种用于治疗或抑制氧化应激紊乱的化合物及其使用方法，包括线粒体紊乱、能量加工障碍、神经退行性疾病和老年性疾病，或用于调节一个或多个能量生物标志物，正常化一个或多个能量生物标志物，或增强一个或多个能量生物标志物，其中所述化合物是生育酚醌衍生物。进一步披露了化合物、组合物和治疗或预防辐射暴露的方法。
• Low Catalyst Loading in Ring-Closing Metathesis Reactions
  作者：Renat Kadyrov

  DOI：10.1002/chem.201202207

  日期：2013.1.14

  conversion into a broad variety of 5–16‐membered heterocyclic compounds. The practicality of this procedure was illustrated in the synthesis of 5–8‐membered N‐tert‐butoxycarbonyl (N‐Boc)‐ and N‐para‐toluenesulfonyl (N‐Ts)‐protected cyclic amines and 9–16‐membered lactones. The synthesis of macrocyclic proline‐based lactams required slightly higher catalyst loadings. Along with monocyclic products, oligomeric

  描述了一种有效的闭环复分解反应程序。在几分钟内可以达到95％的二烯丙基丙二酸二乙酯在稀溶液中的转化率，达到TOF = 4173 min -1，而载有不饱和NHC配体的商业化Ru催化剂的负载量却非常低。通常，仅需50至250 ppm的催化剂即可将近定量转化为多种5-16元杂环化合物。此过程的实用性在5-8元的合成图示ñ -叔丁氧羰基（Ñ -Boc） -和ñ -对甲苯磺酰（Ñ-Ts）保护的环胺和9-16元内酯。大环脯氨酸基内酰胺的合成需要稍高的催化剂负载量。与单环产物一起，分离并表征了寡聚副产物，主要是环二聚体。
• Synthesis of the Tetracyclic ABCD Ring Systems of Madangamines D–F
  作者：Faïza Diaba、Climent Pujol-Grau、Agustín Martínez-Laporta、Israel Fernández、Josep Bonjoch

  DOI：10.1021/ol503586d

  日期：2015.2.6

  Synthesis of the tetracyclic cores of madangamines D–F was achieved, featuring a reductive radical process from an ethoxycarbonyldichloroacetamide to build the morphan nucleus, a Mitsunobu-type aminocyclization toward the common diazatricyclic intermediate, and ring-closing metathesis reactions for the macrocyclization step leading to the 13- to 15-membered rings.

  madangamines D–F的四环核的合成得以实现，其特征在于乙氧基羰基二氯乙酰胺的还原自由基过程，以形成吗啡核，Mitsunobu型氨基环化反应形成常见的二氮三环中间体，以及大环化步骤导致的闭环易位反应，从而导致13至15元环。
• [EN] MACROCYCLIC PYRIDONE COMPOUND AND APPLICATION THEREOF<br/>[FR] COMPOSÉ DE PYRIDONE MACROCYCLIQUE ET SON APPLICATION<br/>[ZH] 大环吡啶酮类化合物及其应用
  申请人：MEDSHINE DISCOVERY INC

  公开号：WO2023006087A1

  公开（公告）日：2023-02-02

  涉及一种大环吡啶酮类化合物，及其在制备治疗相关疾病的药物中的应用。具体涉及式(I)所示化合物及其药学上可接受的盐。