4,6-dihexyl-6-methylcyclohexa-1,3-dienecarbaldehyde | 1071780-41-0

• 分子结构分类: 有机化合物 - 有机氧化合物 - 有机氧化物
• 英文名称: 4,6-dihexyl-6-methylcyclohexa-1,3-dienecarbaldehyde
• CAS: 1071780-41-0
• 化学式: C₂₀H₃₄O
• 分子量: 290.489
• InChiKey: DEMYMBOLBBSDPX-HXUWFJFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.39
• 重原子数：
  21.0
• 可旋转键数：
  11.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  17.07
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为产物：
  描述：

  2-isopropyl-5-methylcyclohexyl (R)-2-((4,6-dihexyl-6-methylcyclohexa-1,3-dienyl)methylene)hydrazinecarboxylate 在 硫酸 、 水 作用下， 以 乙醇 为溶剂， 反应 2.5h， 生成 4,6-dihexyl-6-methylcyclohexa-1,3-dienecarbaldehyde
  参考文献：
  名称：

  Synthesis and cellular effects of cycloterpenals: Cyclohexadienal-based activators of neurite outgrowth

  摘要：

  An unusual class of diterpenoid natural products, 'cycloterpenals' ( with a central cyclohexadienal core), that arise in nature by condensation of retinoids and other isoprenes, have been isolated from a variety of organisms including marine sponges as well as from the human eye. A milk whey protein has also demonstrated the formation of a cycloterpenal derived from beta-ionylidineacetaldehyde. Here, we generate a synthetic library of these molecules where we detail reaction conditions required to effect cross condensation of alpha,beta-unsaturated aldehydes as opposed to homodimerization. The ability of this class of molecules to activate neurite outgrowth activity is reported. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.07.030