N-methyl-7-exo-(benzylaminocarbonyloxy-)-3-oxo-5,9-dioxa-2-azabicyclo[4.3.0] nonane | 1217319-60-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: N-methyl-7-exo-(benzylaminocarbonyloxy-)-3-oxo-5,9-dioxa-2-azabicyclo[4.3.0] nonane
• 英文别名: [(4aS,7S,7aR)-4-methyl-3-oxo-4a,6,7,7a-tetrahydrofuro[3,2-b][1,4]oxazin-7-yl] N-benzylcarbamate
• CAS: 1217319-60-2
• 化学式: C₁₅H₁₈N₂O₅
• 分子量: 306.318
• InChiKey: RHALMFBHSLDXES-YUTCNCBUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  77.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-(benzylaminocarbonyloxy)-5-keto-1,4:3,6-dianhydro-D-glucitol 、 N-甲基羟胺盐酸盐 在 sodium acetate 、 吡啶 、 对甲苯磺酰氯 作用下， 以 乙醇 为溶剂， 反应 4.0h， 以34%的产率得到N-methyl-7-exo-(benzylaminocarbonyloxy-)-3-oxo-5,9-dioxa-2-azabicyclo[4.3.0] nonane
  参考文献：
  名称：

  Isosorbide-based cholinesterase inhibitors; replacement of 5-ester groups leading to increased stability

  摘要：

  Isosorbide-2-carbamate-5-esters are highly potent and selective butyrylcholinesterase inhibitors with potential utility in the treatment of Alzheimer's Disease (AD). They are stable in human plasma but in mouse plasma they undergo hydrolysis at the 5-ester group potentially attenuating in vivo potency. In this paper we explore the role of the 5-position in modulating potency. The focus of the study was to increase metabolic stability while preserving potency and selectivity. Dicarbamates and 5-keto derivatives were markedly less potent than the ester class. The 2-benzylcarbamate-5-benzyl ether was found to be potent (IC50 52 nM) and stable in the presence of mouse plasma and liver homogenate. The compound produces sustained moderate inhibition of mouse butyrylcholinesterase at 1 mg/kg, IP. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.12.052