(3R)-4-tert-Butyloxycarbonyl-3-benzylpiperazin-2-one | 198973-91-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (3R)-4-tert-Butyloxycarbonyl-3-benzylpiperazin-2-one
• 英文别名: 1,1-Dimethylethyl (2R)-3-oxo-2-(phenylmethyl)-1-piperazinecarboxylate；tert-butyl (2R)-2-benzyl-3-oxopiperazine-1-carboxylate
• CAS: 198973-91-0
• 化学式: C₁₆H₂₂N₂O₃
• 分子量: 290.362
• InChiKey: WCQHYEJEGGKFNU-CYBMUJFWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  58.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (3R)-4-tert-Butyloxycarbonyl-3-benzylpiperazin-2-one 、 碘甲烷 在 氢氧化钾 、 三氟乙酸 作用下， 生成 (3R)-3-benzyl-1-methylpiperazin-2-one
  参考文献：
  名称：

  Synthesis of piperazinones and their apllication in constrained mimetics of the growth hormone secretagogue NN703

  摘要：

  The focus of this paper is the chemistry of 2-piperazinones and the use of this building block to restrict the conformational freedom of the growth hormone secretagogue NN703 (currently in clinical development). We exploit classical methods for 2-piperazinone synthesis as well as some novel approaches such as a Boronic Mannich reaction. Finally. we report on the ability of the constrained target compounds to release growth hormone in vitro. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00525-0
• 作为产物：
  描述：

  (2R)-2-(2-(tert-butoxycarbonylamino)ethylamino)-3-phenylpropionic acid methyl ester 在 potassium carbonate 作用下， 以 1,4-二氧六环 、 甲醇 、 水 为溶剂， 生成 (3R)-4-tert-Butyloxycarbonyl-3-benzylpiperazin-2-one
  参考文献：
  名称：

  Synthesis of piperazinones and their apllication in constrained mimetics of the growth hormone secretagogue NN703

  摘要：

  The focus of this paper is the chemistry of 2-piperazinones and the use of this building block to restrict the conformational freedom of the growth hormone secretagogue NN703 (currently in clinical development). We exploit classical methods for 2-piperazinone synthesis as well as some novel approaches such as a Boronic Mannich reaction. Finally. we report on the ability of the constrained target compounds to release growth hormone in vitro. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00525-0

文献信息

• Compounds with growth hormone releasing properties
  申请人：Novo Nordisk A/S

  公开号：US05919777A1

  公开（公告）日：1999-07-06

  The present invention relates to novel compounds of the general formula I ##STR1## which can be used for treating medical disorders resulting from a deficiency in growth hormone.

  本发明涉及一种新型化合物，其通式为I ##STR1## 可用于治疗因生长激素缺乏引起的医学疾病。
• COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES
  申请人：NOVO NORDISK A/S

  公开号：EP0907643B1

  公开（公告）日：2003-01-15
• US5919777A
  申请人：——

  公开号：US5919777A

  公开（公告）日：1999-07-06
• [EN] COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES<br/>[FR] COMPOSES CAPABLES DE LIBERER UNE HORMONE DE CROISSANCE
  申请人：NOVO NORDISK A/S

  公开号：WO1997040023A1

  公开（公告）日：1997-10-30

  (EN) The present invention relates to novel compounds of general formula (I) which can be used for treating medical disorders resulting from a deficiency in growth hormone.(FR) Cette invention concerne de nouveaux composés correspondant à la formule générale (I), lesquels peuvent être utilisés dans le traitement de troubles médicaux résultant d'une déficience en hormone de croissance.