4''-hydroxy-1,1':4',1''-terphenyl-4-carbaldehyde | 1370618-95-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4''-hydroxy-1,1':4',1''-terphenyl-4-carbaldehyde
• 英文别名: 4-[4-(4-Hydroxyphenyl)phenyl]benzaldehyde
• CAS: 1370618-95-3
• 化学式: C₁₉H₁₄O₂
• 分子量: 274.319
• InChiKey: RYWYXVGFIWKHMA-UHFFFAOYSA-N

物化性质

• 沸点：
  497.0±33.0 °C(Predicted)
• 密度：
  1.192±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,3-二氨基苯酚 、 4''-hydroxy-1,1':4',1''-terphenyl-4-carbaldehyde 在 sodium metabisulfite 作用下， 以 乙醇 、 水 为溶剂， 以59%的产率得到4-hydroxy-2-(4-hydroxy[1,1':4',1''-terphenyl]-4-yl)-1H-benzo[d]imidazole
  参考文献：
  名称：

  Synthesis of terphenyl benzimidazoles as tubulin polymerization inhibitors

  摘要：

  A series of new terphenyl benzimidazoles (3a-z and 3aa-ad) were synthesized and evaluated for their anticancer activity. All the 30 compounds have shown moderate to good anticancer potency, however some of the compounds (3j, 3m-t and 3aa-ad) exhibited prominent anticancer potency with GI(50) values ranging from <0.1 to 9.72 mu M. These compounds exhibit G2/M phase arrest and the analysis of tubulin by Western blot experiments in case of 3t and 3ad shows the disturbances that are caused in the ratio of soluble versus polymerized tubulin in cells. Compounds 3t and 3ad are the most promising candidates amongst the series and has the potential to be taken up for further detailed studies either alone or in combination with the existing therapies. (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.01.004
• 作为产物：
  描述：

  4-甲酰基苯硼酸 在 四(三苯基膦)钯 、 sodium carbonate 作用下， 以 甲醇 、 乙醇 、 水 、 甲苯 为溶剂， 反应 2.0h， 生成 4''-hydroxy-1,1':4',1''-terphenyl-4-carbaldehyde
  参考文献：
  名称：

  Synthesis of terphenyl benzimidazoles as tubulin polymerization inhibitors

  摘要：

  A series of new terphenyl benzimidazoles (3a-z and 3aa-ad) were synthesized and evaluated for their anticancer activity. All the 30 compounds have shown moderate to good anticancer potency, however some of the compounds (3j, 3m-t and 3aa-ad) exhibited prominent anticancer potency with GI(50) values ranging from <0.1 to 9.72 mu M. These compounds exhibit G2/M phase arrest and the analysis of tubulin by Western blot experiments in case of 3t and 3ad shows the disturbances that are caused in the ratio of soluble versus polymerized tubulin in cells. Compounds 3t and 3ad are the most promising candidates amongst the series and has the potential to be taken up for further detailed studies either alone or in combination with the existing therapies. (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.01.004

文献信息

• Synthesis of Hydroxy-Substituted<i>p</i>-Terphenyls and some Larger Oligophenylenes<i>via</i>Palladium on Charcoal Catalyzed Suzuki-Miyaura Reaction
  作者：Josef Jansa、Tomáš Řezníček、Roman Jambor、Filip Bureš、Antonín Lyčka

  DOI：10.1002/adsc.201600487

  日期：2017.1.19

  A ligand‐free heterogeneous palladium on charcoal (Pd/C)‐catalyzed Suzuki‐Miyaura cross‐coupling has been performed. The series of substituted p‐terphenyls were prepared in very good yields without exclusion of air and with low catalyst loadings. Moreover, the developed environmentally benign and scalable protocol enables to use electron poor and sterically hindered boronic acids.

  在木炭（Pd / C）催化的Suzuki-Miyaura交叉偶联反应中进行了无配体的非均相钯。一系列取代的对叔苯基制备得非常好，没有排除空气，催化剂用量也很低。而且，开发的环境友好和可扩展的协议使得能够使用电子贫乏和空间受阻的硼酸。
• Surface-modified inorganic substance, method for manufacturing same, resin composition, thermally conductive material, and device
  申请人：FUJIFILM Corporation

  公开号：US10633252B2

  公开（公告）日：2020-04-28

  A surface-modified inorganic substance is obtained by performing surface modification on a inorganic nitride by using an aldehyde compound such as a compound represented by General Formula I. A resin composition contains the surface-modified inorganic substance and a monomer having a group selected from the group consisting of an oxetanyl group, an oxiranyl group, and a (meth)acrylate group. ZZ—XX—CHO  General Formula I In the formula, ZZ represents a group selected from the group consisting of an amino group, a thiol group, a hydroxyl group, an isocyanate group, a carboxyl group, a carboxylic acid anhydride group, an oxetanyl group, an oxiranyl group, and a (meth)acrylate group, and XX represents a divalent linking group.

  通过使用醛化合物（如通式 I 所代表的化合物）对无机氮化物进行表面改性，可获得表 面改性无机物。树脂组合物包含表面改性无机物和单体，单体的基团选自氧杂环丁酰基、环氧丙烷基和（甲基）丙烯酸酯基。 ZZ-XX-CHO 通式 I 式中，ZZ 代表选自由氨基、硫醇基、羟基、异氰酸酯基、羧基、羧酸酐基、氧杂环丁 烯基、环氧丙烷基和(甲基)丙烯酸酯基组成的基团，XX 代表二价连接基团。
• Thermally conductive material, resin composition, and device
  申请人：FUJIFILM Corporation

  公开号：US10774212B2

  公开（公告）日：2020-09-15

  The present invention provides a thermally conductive material containing a disk-like compound as a thermally conductive material having high thermal conductivity and high heat resistance. For example, the present invention provides a thermally conductive material containing a cured substance of a resin composition containing a disk-like compound having two or more functional groups, in which the functional groups are selected from the group consisting of a (meth)acryl group, a (meth)acrylamide group, an oxiranyl group, an oxetanyl group, a hydroxyl group, an amino group, a thiol group, an isocyanate group, a carboxyl group, and a carboxylic acid anhydride group. The present invention also provides a device, which includes the aforementioned thermally conductive material, and the aforementioned resin composition.

  本发明提供了一种含有盘状化合物的导热材料，作为导热材料具有高导热性和高耐热性。例如，本发明提供了一种导热材料，其含有一种树脂组合物的固化物，该树脂组合物含有具有两个或两个以上官能团的盘状化合物，其中官能团选自(甲基)丙烯酰基、(甲基)丙烯酰胺基、环氧丙烷基、环氧乙烷基、羟基、氨基、硫醇基、异氰酸酯基、羧基和羧酸酐基组成的组。本发明还提供了一种装置，其中包括上述导热材料和上述树脂组合物。