2-benzyloxycarbonylaminoethyl-O-(methyl-2,3-di-O-benzoyl-β-D-glucopyranosyluronate)-(1->3)-2-acetamido-4,6-di-O-benzoyl-2-deoxy-β-D-galactopyranoside | 1225203-34-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-benzyloxycarbonylaminoethyl-O-(methyl-2,3-di-O-benzoyl-β-D-glucopyranosyluronate)-(1->3)-2-acetamido-4,6-di-O-benzoyl-2-deoxy-β-D-galactopyranoside
• 英文别名: methyl (2S,3S,4S,5R,6R)-6-[(2R,3R,4R,5R,6R)-5-acetamido-3-benzoyloxy-2-(benzoyloxymethyl)-6-[2-(phenylmethoxycarbonylamino)ethoxy]oxan-4-yl]oxy-4,5-dibenzoyloxy-3-hydroxyoxane-2-carboxylate
• CAS: 1225203-34-8
• 化学式: C₅₃H₅₂N₂O₁₈
• 分子量: 1005.0
• InChiKey: TWTPTDBYHJZQGV-CMRVPKRGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  73
• 可旋转键数：
  25
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  256
• 氢给体数：
  3
• 氢受体数：
  18

反应信息

• 作为产物：
  描述：

  2-benzyloxycarbonylaminoethyl O-(methyl 2,3-di-O-benzoyl-β-D-glucopyranosyluronate)-(1->3)-4,6-di-O-benzoyl-2-deoxy-2-trichloroacetamido-β-D-galactopyranoside 在 铜 、 锌 作用下， 以 溶剂黄146 为溶剂， 反应 24.0h， 以98%的产率得到2-benzyloxycarbonylaminoethyl-O-(methyl-2,3-di-O-benzoyl-β-D-glucopyranosyluronate)-(1->3)-2-acetamido-4,6-di-O-benzoyl-2-deoxy-β-D-galactopyranoside
  参考文献：
  名称：

  Efficient alternative for the reduction of N-trichloroacetyl groups in synthetic chondroitin oligosaccharide intermediates

  摘要：

  An efficient alternative for the reduction of N-trichloroacetyl groups in chondroitin oligosaccharides is reported. It involves the use of Zn-Cu couple in acetic acid, and Was Successfully applied to a large panel of synthetic intermediates useful for the preparation of chondroitin oligomers, a class of natural products with numerous relevant biological functions. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.02.005

文献信息

• Efficient alternative for the reduction of N-trichloroacetyl groups in synthetic chondroitin oligosaccharide intermediates
  作者：Aude Vibert、Chrystel Lopin-Bon、Jean-Claude Jacquinet

  DOI：10.1016/j.tetlet.2010.02.005

  日期：2010.4

  An efficient alternative for the reduction of N-trichloroacetyl groups in chondroitin oligosaccharides is reported. It involves the use of Zn-Cu couple in acetic acid, and Was Successfully applied to a large panel of synthetic intermediates useful for the preparation of chondroitin oligomers, a class of natural products with numerous relevant biological functions. (C) 2010 Elsevier Ltd. All rights reserved.