4-[2,3-dihydro-2-oxo-5-[[[2-(1-pyrrolidinyl)ethyl]amino]sulfonyl]-1H-indol-3-yl]-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid methyl ester | 310443-25-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 4-[2,3-dihydro-2-oxo-5-[[[2-(1-pyrrolidinyl)ethyl]amino]sulfonyl]-1H-indol-3-yl]-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid methyl ester
• 英文别名: Methyl 5-methyl-4-[2-oxo-5-(2-pyrrolidin-1-ylethylsulfamoyl)-1,3-dihydroindol-3-yl]pyrrolo[2,1-f][1,2,4]triazine-6-carboxylate
• CAS: 310443-25-5
• 化学式: C₂₃H₂₆N₆O₅S
• 分子量: 498.563
• InChiKey: VOUNLYITVOORCX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  35
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  143
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• Pyrrolotriazine inhibitors of kinases
  申请人：Hunt T. John

  公开号：US20060128709A1

  公开（公告）日：2006-06-15

  The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2, FGFR-1, PDGFR, HER-1, HER-2, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.

  本发明提供了I式化合物及其药学上可接受的盐。I式化合物抑制生长因子受体的酪氨酸激酶活性，如VEGFR-2、FGFR-1、PDGFR、HER-1、HER-2，因此可用作抗癌剂。I式化合物还可用于治疗通过生长因子受体操作的信号转导途径引起的其他疾病。
• Derivatives of urea and related diamines, methods for their manufacture, and uses therefor
  申请人：Deprez Pierre

  公开号：US20090054463A1

  公开（公告）日：2009-02-26

  The present invention relates generally to compounds represented in Formula I, pharmaceutical compositions comprising them and methods of treating of diseases or disorders related to the function of the calcium sensing receptor. The invention also relates to processes for making such compounds and to intermediates useful in these processes.

  本发明一般涉及代表式I的化合物、包含它们的药物组合物以及治疗与钙感受受体功能相关的疾病或障碍的方法。本发明还涉及制备此类化合物的方法以及在这些过程中有用的中间体。
• PYRROLOTRIAZINE INHIBITORS OF KINASES
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：EP1183033A1

  公开（公告）日：2002-03-06
• EP1183033A4
  申请人：——

  公开号：EP1183033A4

  公开（公告）日：2002-07-17
• JP2003500359A
  申请人：——

  公开号：JP2003500359A

  公开（公告）日：2003-01-07