methyl (3R,6S)-6-(2-methoxy-2-oxoethyl)-5-oxothiomorpholine-3-carboxylate | 1207532-99-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl (3R,6S)-6-(2-methoxy-2-oxoethyl)-5-oxothiomorpholine-3-carboxylate
• CAS: 1207532-99-7
• 化学式: C₉H₁₃NO₅S
• 分子量: 247.272
• InChiKey: RRHQEDPPZYHENI-WDSKDSINSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  107
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  dimethyl 2-[(2R)-2-amino-3-methoxy-3-oxopropyl]sulfanylbutanedioate 以 N,N-二甲基甲酰胺 为溶剂， 反应 6.0h， 生成 methyl (3R,6R)-6-(2-methoxy-2-oxoethyl)-5-oxothiomorpholine-3-carboxylate 、 methyl (3R,6S)-6-(2-methoxy-2-oxoethyl)-5-oxothiomorpholine-3-carboxylate
  参考文献：
  名称：

  Bafilomycins Produced in Culture by Streptomyces spp. Isolated from Marine Habitats Are Potent Inhibitors of Autophagy

  摘要：

  Five new bafilomycins. F (1) to J (5), have been isolated from laboratory Cultures of two Streptomyces spp. obtained front marine sediments collected in British Columbia, and their Structures have been elucidated by detailed analysis of spectroscopic data and the synthesis of model compounds. The new bafilomycins F (1), G (2), H (3), and J (5) alone with several co-occurring known analogues showed potent inhibition of autophagy in microscopy and biochemical assays. The thiomorpholinone fragment present in bafilomycin F (1) has not previously been found in a natural product.

  DOI：

  10.1021/np900632r

文献信息

• Bafilomycins Produced in Culture by <i>Streptomyces</i> spp. Isolated from Marine Habitats Are Potent Inhibitors of Autophagy
  作者：Gavin Carr、David E. Williams、Ana R. Díaz-Marrero、Brian O. Patrick、Helen Bottriell、Aruna D. Balgi、Elizabeth Donohue、Michel Roberge、Raymond J. Andersen

  DOI：10.1021/np900632r

  日期：2010.3.26

  Five new bafilomycins. F (1) to J (5), have been isolated from laboratory Cultures of two Streptomyces spp. obtained front marine sediments collected in British Columbia, and their Structures have been elucidated by detailed analysis of spectroscopic data and the synthesis of model compounds. The new bafilomycins F (1), G (2), H (3), and J (5) alone with several co-occurring known analogues showed potent inhibition of autophagy in microscopy and biochemical assays. The thiomorpholinone fragment present in bafilomycin F (1) has not previously been found in a natural product.