2-(3-bromo-2-methylphenyl)-5-(2-fluoro-4-methoxyphenyl)-1,3,4-oxadiazole | 1220508-39-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-(3-bromo-2-methylphenyl)-5-(2-fluoro-4-methoxyphenyl)-1,3,4-oxadiazole
• CAS: 1220508-39-3
• 化学式: C₁₆H₁₂BrFN₂O₂
• 分子量: 363.186
• InChiKey: DNQUNTIKOMGKPS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  48.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-fluoro-4-methoxybenzohydrazide 、 3-溴-2-甲基苯甲酸 在 三氯氧磷 作用下， 反应 2.0h， 以78%的产率得到2-(3-bromo-2-methylphenyl)-5-(2-fluoro-4-methoxyphenyl)-1,3,4-oxadiazole
  参考文献：
  名称：

  Synthesis, characterization and biological activity of some new 1,3,4-oxadiazole bearing 2-flouro-4-methoxy phenyl moiety

  摘要：

  In the present study a series of new 1,3,4-oxadiazole derivatives containing 2-fluoro-4-methoxy moiety were synthesized. These newly synthesized compounds were characterized by NMR, mass spectral, IR spectral study and also by C, H, N analyses. All the newly synthesized compounds were screened for their antibacterial and antifungal studies. Antimicrobial studies revealed that compounds 4a and 4b showed significant antibacterial activity against Escherichia coli and Pseudomonas aeruginosa Compound 4i showed significant antifungal activity against C. albicans. (C) 2009 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2009.11.046

文献信息

• Synthesis, characterization and biological activity of some new 1,3,4-oxadiazole bearing 2-flouro-4-methoxy phenyl moiety
  作者：B. Chandrakantha、Prakash Shetty、Vijesh Nambiyar、Nishitha Isloor、Arun M. Isloor

  DOI：10.1016/j.ejmech.2009.11.046

  日期：2010.3

  In the present study a series of new 1,3,4-oxadiazole derivatives containing 2-fluoro-4-methoxy moiety were synthesized. These newly synthesized compounds were characterized by NMR, mass spectral, IR spectral study and also by C, H, N analyses. All the newly synthesized compounds were screened for their antibacterial and antifungal studies. Antimicrobial studies revealed that compounds 4a and 4b showed significant antibacterial activity against Escherichia coli and Pseudomonas aeruginosa Compound 4i showed significant antifungal activity against C. albicans. (C) 2009 Elsevier Masson SAS. All rights reserved.