Potassium 4-{3-{3-methoxy-4-{1-(4-bromophenyl)-3-[4-(2-methoxyphenyl)piperazin-1-yl]propoxy}benzoyl}indol-1-yl}butanoate | 173364-65-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: Potassium 4-{3-{3-methoxy-4-{1-(4-bromophenyl)-3-[4-(2-methoxyphenyl)piperazin-1-yl]propoxy}benzoyl}indol-1-yl}butanoate
• 英文别名: Potassium;4-[3-[4-[1-(4-bromophenyl)-3-[4-(2-methoxyphenyl)piperazin-1-yl]propoxy]-3-methoxybenzoyl]indol-1-yl]butanoate
• CAS: 173364-65-3
• 化学式: C₄₀H₄₁BrN₃O₆*K
• 分子量: 778.784
• InChiKey: DPVDYXHUKZBNME-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  3.52
• 重原子数：
  51
• 可旋转键数：
  15
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  96.3
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• INDOLE DERIVATIVE AND MEDICINE CONTAINING THE SAME
  申请人：ZERIA PHARMACEUTICAL CO., LTD.

  公开号：EP0753511A1

  公开（公告）日：1997-01-15

  The present invention relates to an indole derivative represented by formula (1) or a salt thereof, and a pharmaceutical containing the derivative or the salt: [wherein R1 represents lower alkyl; R2 represents hydrogen or phenyl which may be substituted by at least one lower alkyl, lower alkoxy or a halogen atom; R3 represents hydrogen, lower alkyl, lower alkoxy, or phenylalkyloxy which may be substituted by halogen or lower alkyl; R4 represents hydrogen, lower alkyl or lower alkoxy; R5 represents hydrogen or lower alkyl; and n represents an integer of 1 to 5]. This compound has the effects of both blocking α1-adrenergic receptors and inhibiting testosterone 5α-reductases, and is useful as a remedy and/or a preventive for diseases caused by dihydrotestosterone overproduction, such as prostatic hypertrophy, and diseases accompanying the same, such as urination disorder, male pattern alopecia, acne, and so forth.

  本发明涉及一种由式（1）表示的吲哚衍生物或其盐，以及一种含有该衍生物或该盐的药物： [其中 R1 代表低级烷基；R2 代表氢或苯基，可被至少一个低级烷基、低级烷氧基或卤素原子取代；R3 代表氢、低级烷基、低级烷氧基或苯基烷氧基，可被卤素或低级烷基取代；R4 代表氢、低级烷基或低级烷氧基；R5 代表氢或低级烷基；n 代表 1 至 5 的整数]。该化合物具有阻断α1-肾上腺素能受体和抑制睾酮 5α-还原酶的作用，可用于治疗和/或预防双氢睾酮过度分泌引起的疾病，如前列腺肥大，以及伴随前列腺肥大的疾病，如排尿障碍、男性型脱发、痤疮等。
• 4-INDOL-1-YL BUTYRIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF ALPHA1-ADRENERGIC RECEPTORS AND TESTOSTERONE 5ALPHA-REDUCTASES
  申请人：ZERIA PHARMACEUTICAL CO., LTD.

  公开号：EP0753511B1

  公开（公告）日：2001-07-11
• US5760040A
  申请人：——

  公开号：US5760040A

  公开（公告）日：1998-06-02