N-[[(5S)-3-[3,5-difluoro-4-(1-methyl-5,6-dihydro-1,2,4-triazin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide | 1219707-63-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[[(5S)-3-[3,5-difluoro-4-(1-methyl-5,6-dihydro-1,2,4-triazin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide
• CAS: 1219707-63-7
• 化学式: C₁₆H₁₉F₂N₅O₃
• 分子量: 367.355
• InChiKey: CGHKXYGLSDHZGI-LBPRGKRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  77.5
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  、 乙酸酐 、 氯甲酸苄酯 、 (R)-(-)-丁酸缩水甘油酯 在 碳酸氢钠 、 lithium aluminium tetrahydride 、 正丁基锂 作用下， 以 水 、 丙酮 、 四氢呋喃 为溶剂， 反应 1.5h， 以2.7%的产率得到N-[[(5S)-3-[3,5-difluoro-4-(1-methyl-5,6-dihydro-1,2,4-triazin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide
  参考文献：
  名称：

  一种用于预防或治疗分支杆菌疾病的药物

  摘要：

  本发明公开了一种用于预防或治疗分支杆菌疾病的药物。具体来说，公开了一种下列通式I表示的化合物或其药学上可接受的盐、水合物、溶剂化物、配合物或前药在制备用于预防或治疗分支杆菌疾病的药物中的应用，为结核病等的防治提供给了新的途径。

  公开号：

  CN104364240B

文献信息

• Novel Oxazolidinone Derivatives with Cyclic Amidoxime or Cyclic Amidrazone and Pharmaceutical Compositions Thereof
  申请人：Cho Young Lag

  公开号：US20110178293A1

  公开（公告）日：2011-07-21

  Disclosed is a novel oxazolidinone derivative, particularly a novel oxazolidinone compound with a cyclic amidoxime or cyclic amidrazone group. Also disclosed is a pharmaceutical antibiotic composition including a novel oxazolidinone derivative, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof or a pharmaceutically acceptable salt thereof as an effective ingredient. Because the novel oxazolidinone derivative, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof or a pharmaceutically acceptable salt thereof exhibits a wide antibacterial spectrum against resistant bacteria, a low toxicity, and a strong antibacterial activity against Gram-positive and Gram-negative bacteria, it can be usefully used as an antibiotic.
• US8242113B2
  申请人：——

  公开号：US8242113B2

  公开（公告）日：2012-08-14
• [EN] NOVEL OXAZOLIDINONE DERIVATIVES WITH CYCLIC AMIDOXIME OR CYCLIC AMIDRAZONE AND PHARMACEUTICAL COMPOSITIONS THEREOF<br/>[FR] NOUVEAUX DÉRIVÉS D'OXAZOLIDINONE AVEC UNE AMIDOXIME CYCLIQUE OU UNE AMIDRAZONE CYCLIQUE ET COMPOSITIONS PHARMACEUTIQUES LES COMPRENANT
  申请人：LEGOCHEM BIOSCIENCE LTD

  公开号：WO2010036000A2

  公开（公告）日：2010-04-01

  Disclosed is a novel oxazolidinone derivative, particularly a novel oxazolidinone compound with a cyclic amidoxime or cyclic amidrazone group. Also disclosed is a pharmaceutical antibiotic composition including a novel oxazolidinone derivative, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof or a pharmaceutically acceptable salt thereof as an effective ingredient. Because the novel oxazolidinone derivative, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof or a pharmaceutically acceptable salt thereof exhibits a wide antibacterial spectrum against resistant bacteria, a low toxicity, and a strong antibacterial activity against Gram-positive and Gram-negative bacteria, it can be usefully used as an antibiotic.
• 一种用于预防或治疗分支杆菌疾病的药物
  申请人：四川贝力克生物技术有限责任公司

  公开号：CN104364240B

  公开（公告）日：2017-02-22

  本发明公开了一种用于预防或治疗分支杆菌疾病的药物。具体来说，公开了一种下列通式I表示的化合物或其药学上可接受的盐、水合物、溶剂化物、配合物或前药在制备用于预防或治疗分支杆菌疾病的药物中的应用，为结核病等的防治提供给了新的途径。