6-Dipropylamino-5,5-dimethyl-5,6,7,8-tetrahydro-naphthalen-1-ol; hydrobromide | 90295-46-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 6-Dipropylamino-5,5-dimethyl-5,6,7,8-tetrahydro-naphthalen-1-ol; hydrobromide
• 英文别名: 6-(dipropylamino)-5,5-dimethyl-7,8-dihydro-6H-naphthalen-1-ol;hydrobromide
• CAS: 90295-46-8
• 化学式: BrH*C₁₈H₂₉NO
• 分子量: 356.346
• InChiKey: CNOHXYIWLNSBDX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.68
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  23.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  5-methoxy-1,1-dimethyl-2-(di-n-propylamino)tetralin hydrochloride 在 氢溴酸 作用下， 反应 2.0h， 以66%的产率得到6-Dipropylamino-5,5-dimethyl-5,6,7,8-tetrahydro-naphthalen-1-ol; hydrobromide
  参考文献：
  名称：

  C1-Methylated 5-hydroxy-2-(dipropylamino)tetralins: central dopamine-receptor stimulating activity

  摘要：

  C1-Methylated derivatives of the potent dopaminergic agonist 5-hydroxy-2-(di-n-propylamino)tetralin (6) have been synthesized and tested for central dopamine (DA) receptor stimulating activity, by using biochemical and behavioral tests in rats. Both cis- and trans-5-hydroxy-1-methyl-2-(di-n-propylamino) tetralin (4 and 3) may be classified as central DA-receptor agonists, albeit of lower potency than 6. The results obtained indicate that both 4 and 3 display DA-autoreceptor stimulation capacity. However, only one of the isomers, trans-3, is able to elicit clear-cut postsynaptic DA receptor agonist actions at larger doses. 5-Hydroxy-1,1-dimethyl-2-(n-propylamino) tetralin (5) was found to be inactive.

  DOI：

  10.1021/jm00374a012