3-isopropyl-2-methylpyrazolo[1,5-a]pyridine | 605673-35-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并吡啶类
• 英文名称: 3-isopropyl-2-methylpyrazolo[1,5-a]pyridine
• 英文别名: 2-methyl-3-propan-2-ylpyrazolo[1,5-a]pyridine
• CAS: 605673-35-6
• 化学式: C₁₁H₁₄N₂
• 分子量: 174.246
• InChiKey: GEMCVCNHIAFWIO-UHFFFAOYSA-N

物化性质

• 密度：
  1.05±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  17.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-Methyl-3-acetylpyrazolo<1,5-a>pyridin 在 三乙基硅烷 、 三氟乙酸 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 反应 22.0h， 生成 3-isopropyl-2-methylpyrazolo[1,5-a]pyridine
  参考文献：
  名称：

  Novel pyrazolo[1,5-a]pyridine derivatives and their use as neurotransmitter modulators

  摘要：

  本发明涉及一种新型的嘧啶并[1,5-a]吡啶衍生物，其一般化学式为I:1，能够与CRF1受体高亲和力结合，包括人类CRF1受体。本发明还涉及使用本发明的化合物治疗某种疾病或症状的方法，该疾病或症状的治疗可以通过拮抗CRF受体来实现或促进，例如中枢神经系统疾病或疾病，尤其是焦虑症、抑郁症和与压力相关的疾病。

  公开号：

  US20040002511A1

文献信息

• 9H-PYRIMIDO[4,5-B]INDOLES AND RELATED ANALOGS AS BET BROMODOMAIN INHIBITORS
  申请人：THE REGENTS OF THE UNIVERSITY OF MICHIGAN

  公开号：US20150246923A1

  公开（公告）日：2015-09-03

  The present disclosure provides substituted 9H-pyrimido[4,5-b]indoles and 5H-pyrido[4,3-b]indoles and related analogs represented by Formula I: and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R 1a , A, B 1 , B 2 , G, X 1 , Y 1 , Y 2 , and Y 3 are as defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a condition or disorder responsive to inhibition of BET bromodomains. Compounds of the present disclosure are especially useful for treating cancer.

  本公开提供了代表为式I的替代的9H-嘧啶并[4,5-b]吲哚和5H-吡啶并[4,3-b]吲哚及相关类似物的药用可接受的盐、水合物和溶剂合物，其中R1a、A、B1、B2、G、X1、Y1、Y2和Y3如规范中所定义。本公开还涉及使用式I的化合物来治疗对BET溴结构域抑制敏感的状况或疾病。本公开的化合物特别适用于治疗癌症。
• Thiophene-carboxamides useful as inhibitors of protein kinases
  申请人：Brenchley Guy

  公开号：US20070219205A1

  公开（公告）日：2007-09-20

  The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

  本发明涉及用作蛋白激酶抑制剂的化合物。本发明还提供了包含所述化合物的药学上可接受的组合物，并提供了使用该组合物治疗各种疾病、病况或疾患的方法。本发明还提供了制备发明化合物的方法。
• Pyrazolo[1,5-a]pyridine derivatives and their use as neurotransmitter modulators
  申请人：Pharmacia & Upjohn Company LLC

  公开号：US07151109B2

  公开（公告）日：2006-12-19

  The present invention relates to novel pyrazolo[1,5-a]pyridine derivatives of general formula I: that bind with high affifnity to CRF1 receptors, including human CRF1 receptors. This invention also relates to methods of using the compounds of the invention to treat a disorder or condition, the treatment of which can be effected or facilitated by antagonizing a CRF receptor, such as CNS disorders or diseases, particularly anxiety disorders, and depression and stress related disorders.

  本发明涉及一种新型的吡唑并[1,5-a]吡啶衍生物，其通式为I，可以与CRF1受体高亲和结合，包括人类CRF1受体。本发明还涉及使用本发明化合物治疗一种疾病或病症的方法，该病症的治疗可以通过拮抗CRF受体来实现或促进，例如中枢神经系统疾病或疾病，特别是焦虑症，抑郁症和与压力相关的疾病。
• THIOPHENE-CARBOXAMIDES USEFUL AS INHIBITORS OF PROTEIN KINASES
  申请人：Brenchley Guy

  公开号：US20110288095A1

  公开（公告）日：2011-11-24

  The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

  本发明涉及用作蛋白激酶抑制剂的化合物。本发明还提供包含该化合物的药学上可接受的组合物，并提供使用该组合物治疗各种疾病、病况或障碍的方法。本发明还提供制备本发明化合物的方法。
• HETEROARYLS AND USES THEREOF
  申请人：Freeze Brian S.

  公开号：US20120214794A1

  公开（公告）日：2012-08-23

  This invention provides compounds of formula I-A or I-B: wherein HY, G 1 , G 2 , R 2 , R 12 , W 1 , W 2 , n, and Ring A are as described in the specification. The compounds are inhibitors of PI3K and/or mTor and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.

  这项发明提供了I-A或I-B式化合物：其中HY、G1、G2、R2、R12、W1、W2、n和环A的定义如规范中所述。这些化合物是PI3K和/或mTor的抑制剂，因此可用于治疗增殖性、炎症性或心血管疾病。