3-溴丙酸丙酯 | 4890-42-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 3-溴丙酸丙酯
• 英文名称: propyl 3-bromopropanoate
• 英文别名: 3-bromo-propionic acid propyl ester；3-Brom-propionsaeure-propylester
• CAS: 4890-42-0
• 化学式: C₆H₁₁BrO₂
• 分子量: 195.056
• InChiKey: DXFHVUUGWSXHQY-UHFFFAOYSA-N

物化性质

• 熔点：
  169-171 °C(Solv: water (7732-18-5))
• 沸点：
  179.7±13.0 °C(Predicted)
• 密度：
  1.352±0.06 g/cm3(Predicted)
• 保留指数：
  1077

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-溴丙酸丙酯 、 2-mercapto-5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazole 在 氢氧化钾 作用下， 以 乙醇 为溶剂， 生成 Propyl 3-{[5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazol-2-yl)thio}propionate
  参考文献：
  名称：

  某些[5-（硝基芳基）-1,3,4-噻二唑-2-基硫代]丙酸烷基酯的合成及抗分枝杆菌活性。

  摘要：

  合成了两个系列的2-和3- [5-（硝基芳基）-1,3,4-噻二唑-2-基硫代，亚磺酰基和磺酰基]丙酸烷基酯，并使用BACTEC 460筛选了针对结核分枝杆菌H37Rv的抗结核活性辐射测量系统。确定显示超过90％抑制作用的化合物的MIC值。两组数据的比较结果表明，在合成的衍生物中，化合物丙基3- [5-（5-硝基噻吩-2-基）-1,3,4-噻二唑-2-基硫代]丙酸酯最大。活性化合物（MIC = 1.56 microgml（-1））。

  DOI：

  10.1016/j.bmcl.2005.11.087
• 作为产物：
  描述：

  3-溴丙烷酰基溴化物 生成 3-溴丙酸丙酯
  参考文献：
  名称：

  Charlesworth; Anderson, Canadian Journal of Research, Section B: Chemical Sciences, 1950, vol. 28, p. 1,3

  摘要：

  DOI：

文献信息

• Structure–activity relationships for ketamine esters as short-acting anaesthetics
  作者：Jiney Jose、Swarna A. Gamage、Martyn G. Harvey、Logan J. Voss、James W. Sleigh、William A. Denny

  DOI：10.1016/j.bmc.2013.06.047

  日期：2013.9

  aliphatic esters of the non-opioid anaesthetic/analgesic ketamine were prepared and their properties as shorter-acting analogues of ketamine itself were explored in an infused rat model, measuring the time after infusion to recover from both the anaesthetic (righting reflex) and analgesic (response to stimulus) effects. The potency of the esters as sedatives was not significantly related to chain length

  制备了一系列非阿片类麻醉剂/镇痛剂氯胺酮的脂族酯，并在输注的大鼠模型中探索了其作为氯胺酮本身的短效类似物的性质，测量了输注后从两种麻醉剂中恢复的时间（对位反射）和镇痛作用（对刺激的反应）。酯类作为镇静剂的效力与链长没有显着关系，但是Me，Et和i-Pr酯的剂量效价更高（最多比氯胺酮低两倍），而n-Pr酯的效价更低（从2-比氯胺酮少6倍）。对于Me，Et和i-Pr酯，麻醉后的回收率比氯胺酮本身快10–15倍；对于n-Pr酯，麻醉剂的回收率比氯胺酮快20–25倍。
• Polyhydroxyalkanoate having vinyl group, ester group, carboxyl group, and sulfonic group, and method of producing the same
  申请人：Kenmoku Takashi

  公开号：US20070073006A1

  公开（公告）日：2007-03-29

  To provide a novel polyhydroxyalkanoate having a reactive functional group in a molecule and a method of producing the same; and a novel polyhydroxyalkanoate having a new function obtained by chemically modifying the polyhydroxyalkanoate having a reactive functional group and a method of producing the same. By utilizing a vinyl group of a polyhydroxyalkanoate containing a unit having the vinyl group at a side chain thereof, a polyhydroxyalkanoate containing units having a carboxyl group, an amide group, and a sulfonic group in a molecule is induced.

  提供一种分子中具有反应性功能基团的新型聚羟基脂肪酸酯及其制备方法；以及通过化学修饰具有反应性功能基团的聚羟基脂肪酸酯获得的具有新功能的新型聚羟基脂肪酸酯及其制备方法。通过利用聚羟基脂肪酸酯中含有侧链上乙烯基的单元的乙烯基，诱导聚羟基脂肪酸酯中含有羧基、酰胺基和磺酸基的单元。
• Polyhydroxyalkanoic Acid Having Vinyl, Ester, Carboxyl or Sulfonic Acid Group and Producing Method Therefor
  申请人：Kenmoku Takashi

  公开号：US20080064828A1

  公开（公告）日：2008-03-13

  The invention is to provide a novel polyhydroxyalkanoate having a reactive function group within the molecule and a producing method therefor In a polyhydroxyalkanoate containing a unit having a vinyl group in a side chain, such vinyl group is utilized for deriving a polyhydroxyalkanoate comprising a carboxyl group or a unit having an amide group and a sulfonic acid group.

  本发明旨在提供一种新型聚羟基烷酸酯，其分子内具有反应性功能团，并提供其制备方法。在含有侧链中具有乙烯基团的聚羟基烷酸酯中，利用该乙烯基团来获得含有羧基或含有酰胺基和磺酸基的聚羟基烷酸酯。
• Ketamine Derivatives
  申请人：SLEIGH James Wallace

  公开号：US20150259277A1

  公开（公告）日：2015-09-17

  The present invention relates to ketamine derivatives of the formula (I), pharmaceutical compositions comprising them, and methods for treating pain comprising administering them, and their use in the manufacture of medicaments for treating pain. The present invention also relates to methods for anaesthetizing and methods for sedating a subject comprising administering ketamine derivatives of the formula (II).

  本发明涉及公式（I）的氯胺酮衍生物，包括它们的药物组成物，以及用于治疗疼痛的给药方法，以及它们用于制造治疗疼痛药物的用途。本发明还涉及给予公式（II）的氯胺酮衍生物的方法，用于麻醉和镇静受试者的方法。
• Charge control agent, toner, image forming method, and image forming apparatus
  申请人：Yano Tetsuya

  公开号：US20090202927A1

  公开（公告）日：2009-08-13

  To provide: a charge control agent having negative chargeability, which contributes to environmental conservation and the like to an increased degree, has high performance (high charge amount, quick rise-up of charge, excellent stability with time, and high environmental stability), and has improved dispersibility; a toner for developing an electrostatic charge image containing the charge control agent; and an image forming method and an image forming apparatus each using the toner for developing an electrostatic charge image. A charge control agent for controlling a charged state of powder, characterized by including one or more units each represented by the following chemical formula (1) in a molecule.

  提供：一种具有负电荷性能的充电控制剂，可更有效地促进环境保护等，具有高性能（高电荷量，快速电荷上升，优异的时间稳定性和高环境稳定性），并具有改善的分散性；一种包含充电控制剂的用于开发静电充电图像的色调剂；以及使用用于开发静电充电图像的色调剂的图像形成方法和图像形成设备。一种用于控制粉末的带电状态的充电控制剂，其特征在于分子中包含由以下化学式（1）表示的一个或多个单元。