2-aminoethyl decanoate | 211984-65-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-aminoethyl decanoate
• CAS: 211984-65-5
• 化学式: C₁₂H₂₅NO₂
• 分子量: 215.336
• InChiKey: PESNDQQWLWAXDE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  15
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-((tert-butoxycarbonyl)amino)ethyl decanoate 在 三氟乙酸 、 碳酸氢钠 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 0.5h， 以73%的产率得到2-aminoethyl decanoate
  参考文献：
  名称：

  Lipophilic amines as potent inhibitors of N-acylethanolamine-hydrolyzing acid amidase

  摘要：

  N-Acylethanolamines (NAEs) including N-arachidonoylethanolamine (anandamide) and N-palmitoylethanolamine are endogenous lipid mediators. These molecules are degraded to the corresponding fatty acids and ethanolamine by fatty acid amide hydrolase (FAAH) or NAE-hydrolyzing acid amidase (NAAA). Lipophilic amines, especially pentadecylamine (2c) and tridecyl 2-aminoacetate (11b), were found to exhibit potent NAAA inhibitory activities (IC50 = 5.7 and 11.8 mu M), with much weaker effects on FAAH. These simple structures would provide a scaffold for further improvement in NAAA inhibitory activity. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2012.03.065

文献信息

• Rewritable optical information recording medium, recording and reproducing methods, as well as recording and reproducing apparatus
  申请人：Tamada Sakuya

  公开号：US20060088786A1

  公开（公告）日：2006-04-27

  A rewritable optical information recording medium including a recording layer composed of an organic dye film is provided, in which recording and erasing information can be performed reversibly by laser light irradiation. A rewritable optical information recording medium including at least one organic dye film which is substantially made of only at least one kind of organic dye compounds as a recording film is provided. The recording and erasure of information are performed by a reversible physical change of the organic dye film substance caused by laser light irradiation. Specifically, data recording is performed by a physical change locally caused by the irradiation of recording laser light, data reproduction is performed by detecting change in intensity of returned light of reproducing laser light having less power than the recording laser light, and data erasure is performed by applying at least once continuous light or pulse light having laser power more than the reproducing laser light and less than the recording laser light. The physical change is a change in shape.
• ETHANOLAMINE-BASED LIPID BIOSYNTHETIC COMPOUNDS, METHOD OF MAKING AND USE THEREOF
  申请人：NOVAZOI THERANOSTICS

  公开号：US20170273995A1

  公开（公告）日：2017-09-28

  A method for treating cancer is disclosed. The method comprises administering to a subject in need thereof, an effective amount of a pharmaceutical composition comprising monoethanolamine, its prodrug or hybrid molecule or a pharmaceutically acceptable salt thereof, and a pharmaceutically effective carrier. Also disclosed is a composition comprising monoethanolamine or a pharmaceutically acceptable salt thereof and a pharmaceutically effective carrier, wherein the pharmaceutical composition is formulated for oral, intravenous, intraperitoneal, subcutaneous, dermal, or intranasal administration.
• [EN] LIPID COMPOSITION<br/>[FR] COMPOSITION LIPIDIQUE<br/>[JA] 脂質組成物
  申请人：FUJIFILM CORP

  公开号：WO2021095876A1

  公开（公告）日：2021-05-20

  本発明の課題は、幅広い種類の核酸について優れた核酸送達を実現できる脂質組成物を提供することである。本発明によれば、式（１）で表される脂質又はその塩である第一の脂質、ステロール類、および核酸を含む脂質組成物であって、脂質組成物中の第一の脂質のモル数の、脂質組成物中のステロール類のモル数に対する比が０．３００以上１．２９９未満である、脂質組成物が提供される。式中、Ｘは－ＮＲ１－または－Ｏ－を示し、Ｒ１は、水素原子、炭化水素基等を示し、Ｒ２およびＲ３はそれぞれ独立に、水素原子、炭化水素基等を示し、Ｒ４、Ｒ５、Ｒ６、Ｒ７、Ｒ８、Ｒ９、Ｒ１０、Ｒ１１、およびＲ１２はそれぞれ独立に、水素原子またはアルキル基を示し、 Ｒ４およびＲ５、Ｒ１０およびＲ５、Ｒ５およびＲ１２、Ｒ４およびＲ６、Ｒ５およびＲ６、Ｒ６およびＲ７、Ｒ６およびＲ１０、Ｒ１２およびＲ７、並びにＲ７およびＲ８の何れか一組以上は互いに連結してＯ原子を含んでいてもよい４～７員環を形成してもよく、ａ、ｂ、ｃ、およびｄはそれぞれ独立に０～３の整数を示し、但し、ａ＋ｂは１以上であり、ｃ＋ｄは１以上である。
• Lipophilic amines as potent inhibitors of N-acylethanolamine-hydrolyzing acid amidase
  作者：Yumiko Yamano、Kazuhito Tsuboi、Yuki Hozaki、Kiyohiro Takahashi、Xing-Hua Jin、Natsuo Ueda、Akimori Wada

  DOI：10.1016/j.bmc.2012.03.065

  日期：2012.6

  N-Acylethanolamines (NAEs) including N-arachidonoylethanolamine (anandamide) and N-palmitoylethanolamine are endogenous lipid mediators. These molecules are degraded to the corresponding fatty acids and ethanolamine by fatty acid amide hydrolase (FAAH) or NAE-hydrolyzing acid amidase (NAAA). Lipophilic amines, especially pentadecylamine (2c) and tridecyl 2-aminoacetate (11b), were found to exhibit potent NAAA inhibitory activities (IC50 = 5.7 and 11.8 mu M), with much weaker effects on FAAH. These simple structures would provide a scaffold for further improvement in NAAA inhibitory activity. (C) 2012 Elsevier Ltd. All rights reserved.