1-Butyl-2,3-dihydro-1H-indole-5-carbaldehyde | 313479-66-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-Butyl-2,3-dihydro-1H-indole-5-carbaldehyde
• 英文别名: 1-butyl-2,3-dihydroindole-5-carbaldehyde
• CAS: 313479-66-2
• 化学式: C₁₃H₁₇NO
• mdl: MFCD08753177
• 分子量: 203.28
• InChiKey: VWFUZSFVSZMSNV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• N-Haloalkylindoline Intermediates, Their Process And Use In Preparation of Silodosin And its Derivatives
  申请人：MANKIND RESEARCH CENTRE

  公开号：US20160046577A1

  公开（公告）日：2016-02-18

  The present invention provides novel indoline compounds, derivatives of Formula 1 and salts thereof; which can be effectively used for the preparation of a1-adrenoceptor antagonists, Silodosin and its pharmaceutically acceptable salts.

  本发明提供了新型的吲哚啉化合物，公式1的衍生物和其盐；可有效用于制备a1-肾上腺素受体拮抗剂Silodosin及其药学上可接受的盐。
• RHODANINE DERIVATIVES FOR USE IN A METHOD OF INHIBITING AMYLOID PROTEIN AGGREGATION AND IMAGING AMYLOID DEPOSITS
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP1192143A1

  公开（公告）日：2002-04-03
• Novel Intermediates, their Process And Use In Preparation of Selective a1-Adrenoceptor Antagonists, Silodosin
  申请人：Mankind Research Centre

  公开号：US20180111901A1

  公开（公告）日：2018-04-26

  The present invention provides novel process for the preparation of the α1-adrenoceptor antagonists, Silodosin and its pharmaceutically acceptable salts indoline compounds, utilizing derivatives of Formula 1 and salts thereof.
• US9862681B2
  申请人：——

  公开号：US9862681B2

  公开（公告）日：2018-01-09
• [EN] RHODANINE DERIVATIVES FOR USE IN A METHOD OF INHIBITING AMYLOID PROTEIN AGGREGATION AND IMAGING AMYLOID DEPOSITS<br/>[FR] DERIVES DE RHODANINE UTILISES DANS UN PROCEDE D'INHIBITION DE L'AGREGATION DE PROTEINES AMYLOIDES ET DE FORMATION D'IMAGES DE DEPOTS AMYLOIDES
  申请人：WARNER LAMBERT CO

  公开号：WO2000076987A1

  公开（公告）日：2000-12-21

  The present invention provides a method of treating Alzheimer's disease using a compound of Formula (I). Also provided is a method of inhibiting the aggregation of amyloid proteins using a compound of Formula (I) and a method of imaging amyloid deposits using compounds of Formula (I).