S-(2-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)ethyl)ethanethioate | 1225437-78-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: S-(2-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)ethyl)ethanethioate
• 英文别名: S-2-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)ethyl ethanethioate；S-(2-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)ethyl) ethanethioate；S-[2-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)ethyl] ethanethioate
• CAS: 1225437-78-4
• 化学式: C₉H₁₄N₂O₃S
• 分子量: 230.288
• InChiKey: PILRUUPMJIXYDH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  91.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  S-(2-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)ethyl)ethanethioate 在 双氧水 、 caesium carbonate 、 sodium hydroxide 作用下， 以 甲醇 、 甲酸 、 N,N-二甲基甲酰胺 为溶剂， 反应 40.0h， 生成
  参考文献：
  名称：

  Novel N-chloroheterocyclic antimicrobials

  摘要：

  Antimicrobial compounds with broad-spectrum activity and minimal potential for antibiotic resistance are urgently needed. Toward this end, we prepared and investigated a novel series of N-chloroheterocycles. Of the compounds examined, the N-chloroamine series were found superior over N-chloroamide series in regards to exhibiting high antimicrobial activity, low cytotoxicity, and long-term aqueous stability. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.03.035
• 作为产物：
  描述：

  5,5-二甲基海因 在 sodium hydroxide 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 36.0h， 生成 S-(2-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)ethyl)ethanethioate
  参考文献：
  名称：

  Novel N-chloroheterocyclic antimicrobials

  摘要：

  Antimicrobial compounds with broad-spectrum activity and minimal potential for antibiotic resistance are urgently needed. Toward this end, we prepared and investigated a novel series of N-chloroheterocycles. Of the compounds examined, the N-chloroamine series were found superior over N-chloroamide series in regards to exhibiting high antimicrobial activity, low cytotoxicity, and long-term aqueous stability. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.03.035

文献信息

• [EN] ANTIMICROBIAL OXAZOLIDINONE, HYDANTOIN AND IMIDAZOLIDINONE COMPOSITIONS<br/>[FR] COMPOSITIONS ANTIMICROBIENNES D'OXAZOLIDINONE, D'HYDANTOÏNE ET D'IMIDAZOLIDINONE
  申请人：NOVABAY PHARMACEUTICALS INC

  公开号：WO2010054009A1

  公开（公告）日：2010-05-14

  The present application relates to N-chlorinated oxazolidinone, hydantoin and imidazolidinone compounds of Formula (I): or pharmaceutically acceptable salts thereof, and associated compositions and methods of use as antimicrobial agents.

  本申请涉及Formula (I)中的N-氯代噁唑烷二酮、海因酮和咪唑烷二酮化合物，或其药用可接受的盐，以及相关的组合物和用作抗微生物剂的方法。
• ANTIMICROBIAL OXAZOLIDINONE, HYDANTOIN AND IMIDAZOLIDINONE COMPOSITIONS
  申请人：Jain Rakesh K.

  公开号：US20100137349A1

  公开（公告）日：2010-06-03

  The present application relates to N-chlorinated oxazolidinone, hydantoin and imidazolidinone compounds of Formula I or pharmaceutically acceptable salts thereof, and associated compositions and methods of use as antimicrobial agents.

  本申请涉及公式I的N-氯代噁唑烷酮，脲和咪唑烷酮化合物或其药学上可接受的盐，以及相关的组合物和用作抗微生物剂的方法。
• Substituted N,N-dihaloamines as antimicrobials
  申请人：Jain Rakesh K.

  公开号：US09248117B2

  公开（公告）日：2016-02-02

  The present application describes compounds of Formula I: which are antimicrobial agents, including antibacterial, disinfectant, antifungal, germicidal and/or antiviral agents.

  本申请描述了I式化合物，这些化合物是抗微生物剂，包括抗菌剂、消毒剂、抗真菌剂、杀菌剂和/或抗病毒剂。
• [EN] ANTIMICROBIAL POLYETHER AND POLYOL COMPOUNDS<br/>[FR] COMPOSÉS POLYÉTHER ET POLYOL ANTIMICROBIENS
  申请人：NOVABAY PHARMACEUTICALS INC

  公开号：WO2012054521A8

  公开（公告）日：2012-08-30
• Antimicrobial Polyether and Polyol Compounds
  申请人：Jain Rakesh K.

  公开号：US20120129793A1

  公开（公告）日：2012-05-24

  The present application describes compounds of Formula I and Formula IA and as disclosed herein, that are useful as anti-microbial agents, including as antibacterial, disinfectant, antifungal, germicidal or antiviral agents.