Cys-Gln | 629653-15-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Cys-Gln
• 英文别名: cisteinylglutamine；L-Cysteinyl-L-glutamine；(2S)-5-amino-2-[[(2R)-2-amino-3-sulfanylpropanoyl]amino]-5-oxopentanoic acid
• CAS: 629653-15-2
• 化学式: C₈H₁₅N₃O₄S
• 分子量: 249.291
• InChiKey: YHDXIZKDOIWPBW-WHFBIAKZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  137
• 氢给体数：
  5
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  Cys-Gln 在 盐酸 、 乙二胺四乙酸 、 sodium nitrite 作用下， 以 水 为溶剂， 反应 0.17h， 生成 S-nitrosocysteinylglutamine
  参考文献：
  名称：

  Mechanism-Based Triarylphosphine-Ester Probes for Capture of Endogenous RSNOs

  摘要：

  Nitrosothiols (RSNOs) have been proposed as important intermediates in nitric oxide (NO center dot) metabolism, storage, and transport as well as mediators in numerous NO. signaling pathways. RSNO levels are finely regulated, and dysregulation is associated with the etiology of several pathologies. Current methods for RSNO quantification depend on indirect assays that limit their overall specificity and reliability. Recent developments of phosphine-based chemical probes constitute a promising approach for the direct detection of RSNOs. We report here results from a detailed mechanistic and kinetic study for trapping RSNOs by three distinct phosphine probes, including structural identification of novel intermediates and stability studies under physiological conditions. We further show that a triarylphosphine-thiophenyl ester can be used in the absolute quantification of endogenous GSNO in several cancer cell lines, while retaining the elements of the SNO functional group, using an LC-MS-based assay. Finally, we demonstrate that a common product ion (m/z = 309.0), derived from phosphine RSNO adducts, can be used for the detection of other low-molecular weight nitrosothiols (LMW-RSNOs) in biological samples. Collectively, these findings establish a platform for the phosphine ligation-based, specific and direct detection of RSNOs in biological samples, a powerful tool for expanding the knowledge of the biology and chemistry of NO center dot-mediated phenomena.

  DOI：

  10.1021/ja401565w

文献信息

• Compositions to improve tic disorders
  申请人：Ozeki Makoto

  公开号：US20060217321A1

  公开（公告）日：2006-09-28

  Tic disorders can be improved by administering theanine, an amino acid that crosses the blood-brain barrier, or a dipeptide consisting of theanine and a different amino acid. In addition, these compositions can be added to foods and drinks or pharmaceuticals.

  滴状障碍可以通过给予茶氨酸改善，这是一种可以穿过血脑屏障的氨基酸，或者是由茶氨酸和另一种氨基酸组成的二肽。此外，这些组合物可以添加到食品和饮料或药品中。
• Cosmetic composition containing hair-growth promoter
  申请人：UNILEVER PLC

  公开号：EP0571198A1

  公开（公告）日：1993-11-24

  A composition suitable for topical application to mammalian skin and hair for inducing, maintaining or increasing hair growth comprises a hair growth promoter chosen from glutamine derivatives and salts thereof. The composition preferably also comprises an activity enhancer which may be chosen from hair growth stimulants, penetration enhancers and cationic polymers.

  一种适用于哺乳动物皮肤和毛发的外用组合物，可诱导、维持或增加毛发生长，其中包括一种毛发生长促进剂，选自谷氨酰胺衍生物及其盐类。该组合物最好还包含一种活性增强剂，它可以选自毛发生长刺激剂、渗透增强剂和阳离子聚合物。
• Glutamine or glutamine-containing dipeptide in a specific dosage for the treatment of inflammation
  申请人：Biotempt B.V.

  公开号：EP2106791A1

  公开（公告）日：2009-10-07

  Described are methods of treating or preventing an inflammation by administering to a patient in need thereof a pharmacologic dose of glutamine or a glutamine-containing dipeptide in a pharmaceutically acceptable carrier, wherein said dose is selected from a range of 0.09 to 90mg glutamine per kg bodyweight of the patient.

  描述了治疗或预防炎症的方法，给有需要的患者施用药理剂量的谷氨酰胺或含谷氨酰胺二肽的药学上可接受的载体，其中所述剂量选自患者每公斤体重 0.09 至 90 毫克谷氨酰胺的范围。
• Glutamine for use in treating injury
  申请人：Wischmeyer Paul

  公开号：US20050059610A1

  公开（公告）日：2005-03-17

  A method of treating a problem relating to tissue metabolism by administering to a patient in need a single dose of glutamine in a pharmaceutically acceptable carrier. Also provided is glutamine for the treatment of an injury relating to tissue metabolism and for preventing cardiac cell damage. A therapeutic composition for treating and preventing cellular metabolic injury, preventing cardiac cell damage, and increasing heat shock protein expression where in the therapeutic includes a single dose of glutamine in a pharmaceutically acceptable carrier is also provided. A method of increasing the expression of heat shock proteins by administering a single dose of glutamine in a pharmaceutically acceptable carrier to a location in need is further provided.

  一种治疗与组织代谢有关的问题的方法，通过向有需要的患者施用单剂量谷氨酰胺，并将其置于药学上可接受的载体中。还提供了用于治疗与组织代谢有关的损伤和预防心脏细胞损伤的谷氨酰胺。还提供了一种用于治疗和预防细胞代谢损伤、预防心脏细胞损伤和增加热休克蛋白表达的治疗组合物，其中治疗物包括药学上可接受的载体中的单剂量谷氨酰胺。此外，还提供了一种通过向有需要的部位施用单剂量谷氨酰胺在药学上可接受的载体中来增加热休克蛋白表达的方法。
• GLUTAMINE FOR USE IN TREATING INJURY
  申请人：University of Colorado

  公开号：EP1663283A1

  公开（公告）日：2006-06-07