12-[N-(5-oxohexanoyl)-l-phenylalanyl-l-glutamyl-l-phenylalanyl-glycinyl]-aminododecyl O-(β-d-galactopyranosyl)-(1→4)-2-acetamido-2-deoxy-β-d-glucopyranoside | 1036637-21-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 12-[N-(5-oxohexanoyl)-l-phenylalanyl-l-glutamyl-l-phenylalanyl-glycinyl]-aminododecyl O-(β-d-galactopyranosyl)-(1→4)-2-acetamido-2-deoxy-β-d-glucopyranoside
• 英文别名: (4S)-5-[[(2S)-1-[[2-[12-[(2R,3R,4R,5S,6R)-3-acetamido-4-hydroxy-6-(hydroxymethyl)-5-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxydodecylamino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-5-oxo-4-[[(2S)-2-(5-oxohexanoylamino)-3-phenylpropanoyl]amino]pentanoic acid
• CAS: 1036637-21-4
• 化学式: C₅₇H₈₆N₆O₁₉
• 分子量: 1159.34
• InChiKey: DZYMOLRKMYQWEJ-DDPFWLLJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  82
• 可旋转键数：
  38
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  387
• 氢给体数：
  13
• 氢受体数：
  19

反应信息

• 作为产物：
  描述：

  芴甲氧羰基-L-谷氨酸-Γ-苄脂 在 palladium 10% on activated carbon 、 β1,4-galactosyltransferase 、 1-羟基苯并三唑 、 O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 、 N,N-二异丙基乙胺 、 γ-环糊精 、 manganese(ll) chloride 作用下， 以 1,4-二氧六环 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 9.05h， 生成 12-[N-(5-oxohexanoyl)-l-phenylalanyl-l-glutamyl-l-phenylalanyl-glycinyl]-aminododecyl O-(β-d-galactopyranosyl)-(1→4)-2-acetamido-2-deoxy-β-d-glucopyranoside
  参考文献：
  名称：

  Studies of cyclodextrin effect for glycosylation by galactosyltransferase

  摘要：

  Cyclodextrins (CDs) do not disturb HPLC purification and do not form lather, which makes them superior to commonly used surfactants. In this paper, the authors describe the utility of CDs, specifically alpha-CD, beta-CD, and gamma-CD, for the synthesis of neoglycolipids from insoluble peptide-linked substrates. gamma-CD was found to be well matched to the bulky benzyl group and accelerated the reaction for the substrate having Phe (F), while beta-CD was well matched to the methyl group and accelerated the reaction for the substrate having Ala (A). Galactosylation to water-insoluble peptide-linked glucosaminide substrate by galactosyltransferase proceeded 63% at the most, but using either beta-CD or gamma-CD gave quantitative yield within 10 h. (c) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.03.058

文献信息

• Chemical and enzymatic synthesis of neoglycolipids in the presence of cyclodextrins
  作者：Izuru Nagashima、Hiroki Shimizu、Takahiko Matsushita、Shin-Ichiro Nishimura

  DOI：10.1016/j.tetlet.2008.03.103

  日期：2008.5

  The efficiency of cyclodextrins (CDs), alpha-CD, beta-CD and gamma-CD, for the blotting of hydrophobic substrates to water-soluble polymers and for the synthesis of neoglycolipids using glycosyltransferase is described. CDs did not disturb HPLC purification and did not bring lather. These merits are superior to surfactants commonly used in such a case. The utility of CDs as a novel and efficient supporting material for enzymatic glycosylation is also discussed. (C) 2008 Elsevier Ltd. All rights reserved.