2-(4-chlorophenyl)thiophene-4-carboxylic acid | 130674-34-9

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 2-(4-chlorophenyl)thiophene-4-carboxylic acid
• 英文别名: 5-(4-Chlorophenyl)thiophene-3-carboxylic acid
• CAS: 130674-34-9
• 化学式: C₁₁H₇ClO₂S
• mdl: MFCD23750145
• 分子量: 238.694
• InChiKey: MFGBEAIHRUCLKX-UHFFFAOYSA-N

物化性质

• 沸点：
  418.7±35.0 °C(Predicted)
• 密度：
  1.415±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  65.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  methyl 5-(4-chlorophenyl)thiophene-3-carboxylate 在 氢氧化钾 作用下， 以 四氢呋喃 、 甲醇 、 水 为溶剂， 反应 4.0h， 以86%的产率得到2-(4-chlorophenyl)thiophene-4-carboxylic acid
  参考文献：
  名称：

  Synthesis and structure–activity relationships of 5-phenylthiophenecarboxylic acid derivatives as antirheumatic agents

  摘要：

  5-(Phenylthiophene)-3-carboxylic acid (2a), a metabolite of esonarimod (1), which was developed as a new antirheumatic drug, was considered as a lead compound for new antirheumatic drugs. A new series of 2a derivatives were synthesized and their characteristic pharmacological effects, that is their antagonistic effect toward interleukin (IL)-1 in mice and the suppressive effect against adjuvant-induced arthritis (AIA) in rats, were evaluated and compared with those of 1. The structure-activity relationships indicated that [5-(4-bromophenyl)- thiophen-3-yl]acetic acid (5d), methyl [5-(4-chlorophenyl)-thiophen-3-yl]acetate acid (5d), and methyl [5-(4-bromophenyl)-thiophen-3-yl]acetate (5i) suppressed AIA more potently than 1 and all of the other synthesized compounds. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2003.08.009

文献信息

• 롤 화장지 인출장치
  申请人：HAN MOON KYO 한문교(419980413753)

  公开号：KR20150002661U

  公开（公告）日：2015-07-08

  본 고안은 롤 화장지 걸이대에 간편하게 장비되어 롤 화장지를 사용자가 필요한 길이로 감아 절취한 상태에서 측면 이탈 시에 구김이나 찢김 없이 용이한 인출이 제공되어 편리성이 보장되는 롤 화장지 인출장치를 제공하는 것을 목적으로 하고 있다. 본 고안의 상기 목적은 벽체에 설치되는 케이스의 내부 상측에 구비된 롤축에 중심지관으로 끼움 된 롤 화장지를 케이스의 하부로 인출하여 ‘ㄷ’자형 회전날개에 의해 소정 길이로 감고, 상기 회전날개에 감겨진 화장지를 측면으로 빼내 사용하도록 롤 화장지의 인출장치에 있어서, 상기 ‘ㄷ’자형 회전날개의 내측에 다른 ‘ㄷ’자형의 지지날개를 구비하여 상호 간이 교차 상태로 하여 각각의 회전날개와 지지날개의 외주에 롤 화장지를 소정 길이로 권취한 후 절취하고, 상기 지지날개의 역 회전에 의해 롤 화장지의 감김상태를 느슨하게 한 상태에서 측면으로 빼어 사용할 수 있도록 구성한 것을 특징으로 하는 롤 화장지 인출장치에 의해 달성된다..

  该设想旨在提供一种方便使用者将卷纸卫生纸卷取到所需长度并剪断后，当侧面脱落时能够轻松取出而无褶皱或撕裂的卷纸卫生纸取出装置，以确保便利性。该设想的上述目的通过提供一种卷纸卫生纸取出装置实现，该装置包括在安装在墙体上的盒体内部上侧配备的卷芯，通过将装有卷纸卫生纸的卷芯插入盒体底部以提取，并通过“ㄷ”字形旋转翼片将其卷成适当长度，然后从侧面取出使用的卷纸卫生纸取出装置，其中，在卷纸卫生纸取出装置中，通过在“ㄷ”字形旋转翼片的内侧配备另一个“ㄷ”字形支撑翼片，使其相互交叉状态，然后在每个旋转翼片和支撑翼片的外周上将卷纸卫生纸卷取到适当长度后剪断，并通过支撑翼片的反向旋转使卷纸卫生纸的卷曲状态变松，从而使其能够从侧面取出并使用。
• AMIDOPYRIDINE DERIVATIVE AND USE THEREOF
  申请人：Mitsubishi Tanabe Pharma Corporation

  公开号：US20150065715A1

  公开（公告）日：2015-03-05

  The present invention relates to novel amidopyridine derivatives. More specifically, the present invention provides a medicinal agent which is useful as a prophylactic or therapeutic agent for diseases based on the production of cytokines from T cells, comprising as the active ingredient an amidopyridine derivative or a pharmacologically acceptable salt thereof. Provided are an amidopyridine derivative of the following general formula (I): wherein each symbol has the same meaning as defined in the description, or a pharmacologically acceptable salt thereof.

  本发明涉及新型的酰胺吡啶衍生物。更具体地说，本发明提供了一种药物剂，其作为预防或治疗基于T细胞产生细胞因子的疾病的药物剂，包括酰胺吡啶衍生物或其药理学上可接受的盐作为活性成分。提供了以下一般式（I）的酰胺吡啶衍生物，其中每个符号具有与描述中定义的相同含义，或其药理学上可接受的盐。
• AMIDOPYRIDINE DERIVATIVE, AND USE THEREOF
  申请人：Mitsubishi Tanabe Pharma Corporation

  公开号：EP2837627A1

  公开（公告）日：2015-02-18

  The present invention relates to novel amidopyridine derivatives. More specifically, the present invention provides a medicinal agent which is useful as a prophylactic or therapeutic agent for diseases based on the production of cytokines from T cells, comprising as the active ingredient an amidopyridine derivative or a pharmacologically acceptable salt thereof. Provided are an amidopyridine derivative of the following general formula (I): wherein each symbol has the same meaning as defined in the description, or a pharmacologically acceptable salt thereof.

  本发明涉及新型氨基吡啶衍生物。更具体地说，本发明提供了一种可作为预防或治疗基于 T 细胞产生细胞因子的疾病的药物，其活性成分包括脒基吡啶衍生物或其药理学上可接受的盐。本发明提供了以下通式(I)的脒基吡啶衍生物： 其中各符号的含义与描述中所定义的相同，或其药理学上可接受的盐。
• US9527859B2
  申请人：——

  公开号：US9527859B2

  公开（公告）日：2016-12-27