2-[1-(furan-2-yl)-2-nitropropyl]-1H-pyrrole | 1210053-77-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 2-[1-(furan-2-yl)-2-nitropropyl]-1H-pyrrole
• CAS: 1210053-77-2
• 化学式: C₁₁H₁₂N₂O₃
• 分子量: 220.228
• InChiKey: IVVYHRDSUOLFJB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  74.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  吡咯 、 2-[(E)-2-硝基丙-1-烯基]呋喃 在 silica gel 作用下， 反应 0.08h， 以83%的产率得到2-[1-(furan-2-yl)-2-nitropropyl]-1H-pyrrole
  参考文献：
  名称：

  Microwave-Assisted Conjugate Addition of Pyrrole on Electron-Deficient Nitro-Olefins

  摘要：

  Michael addition of pyrrole to -nitrovinyl compounds were carried out using microwave methodology. Monosubstituted pyrroles were obtained selectively in a major amount. Formation of novel product obtained during one of the reactions was explained by the double addition to nitrostyrene.

  DOI：

  10.1080/00397910903458025

文献信息

• Microwave-Assisted Conjugate Addition of Pyrrole on Electron-Deficient Nitro-Olefins
  作者：Radhika S. Kusurkar、Nabil A. H. Alkobati

  DOI：10.1080/00397910903458025

  日期：2010.1.14

  Michael addition of pyrrole to -nitrovinyl compounds were carried out using microwave methodology. Monosubstituted pyrroles were obtained selectively in a major amount. Formation of novel product obtained during one of the reactions was explained by the double addition to nitrostyrene.