4-(3-Amino-4-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)-1,3-thiazol-2-one | 1193679-58-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-(3-Amino-4-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)-1,3-thiazol-2-one
• CAS: 1193679-58-1
• 化学式: C₁₉H₂₀N₂O₅S
• 分子量: 388.444
• InChiKey: SQTRKRMDJOYKIW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  109
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  4-(4-Methoxy-3-nitrophenyl)-3-(3,4,5-trimethoxyphenyl)-1,3-thiazol-2-one 在 tin(II) chloride dihdyrate 作用下， 以 乙醇 为溶剂， 反应 2.0h， 生成 4-(3-Amino-4-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)-1,3-thiazol-2-one
  参考文献：
  名称：

  Synthesis and anticancer activity of novel 3,4-diarylthiazol-2(3H)-ones (imines)

  摘要：

  A series of 3,4-diarylthiazol-2(3H)-ones and three 3,4-diarylthiazol-2(3H)-imines were synthesized and evaluated for their cytotoxicity in a panel of human cancer cell lines. Compounds 21 and 22 showed potential anticancer activity against human CEM cells with IC50 values of 0.12 and 0.24 mu M, respectively. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.08.025

文献信息

• Synthesis and anticancer activity of novel 3,4-diarylthiazol-2(3H)-ones (imines)
  作者：Zong-Ying Liu、Yue-Ming Wang、Zhuo-Rong Li、Jian-Dong Jiang、David W. Boykin

  DOI：10.1016/j.bmcl.2009.08.025

  日期：2009.10

  A series of 3,4-diarylthiazol-2(3H)-ones and three 3,4-diarylthiazol-2(3H)-imines were synthesized and evaluated for their cytotoxicity in a panel of human cancer cell lines. Compounds 21 and 22 showed potential anticancer activity against human CEM cells with IC50 values of 0.12 and 0.24 mu M, respectively. (C) 2009 Elsevier Ltd. All rights reserved.