| 1300556-04-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• CAS: 1300556-04-0
• 化学式: C₂₆H₃₇N₇O
• 分子量: 463.626
• InChiKey: CBZFMIISCMCSFQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.28
• 重原子数：
  34.0
• 可旋转键数：
  19.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  125.11
• 氢给体数：
  1.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  在 dimethyl sulfide borane 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 48.0h， 生成 3-[3-[3-[3-[Bis[3-[bis(2-cyanoethyl)amino]propyl]amino]propyl-[2-(4-hydroxyphenyl)ethyl]amino]propyl-[3-[bis(2-cyanoethyl)amino]propyl]amino]propyl-(2-cyanoethyl)amino]propanenitrile
  参考文献：
  名称：

  A new poly(propylene imine) dendron as potential convenient building-block in the construction of multifunctional systems

  摘要：

  The synthesis of a novel third generation poly(propylene imine) dendron (PPI dendron) is described herein. The dendritic focal point was attached to a tetraethylene glycol spacer that was terminated with a Tmob-protected thiol in order to both avoid any side-reaction during functionalization of dendritic branches as well as enable convenient integration of the dendron into diverse complex systems. The protonation of the final PPI dendron at pH 4-5 is predicted to induce lysosomal degradation through the proton-sponge effect, and therefore enable cytosolic release. These features make the prepared dendron a very convenient building-block for use in the construction of larger systems, such as multifunctional drug delivery vehicles. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.01.070
• 作为产物：
  描述：

  对羟基苯乙胺 在 dimethyl sulfide borane 、 溶剂黄146 作用下， 以 四氢呋喃 为溶剂， 反应 72.0h， 生成
  参考文献：
  名称：

  A new poly(propylene imine) dendron as potential convenient building-block in the construction of multifunctional systems

  摘要：

  The synthesis of a novel third generation poly(propylene imine) dendron (PPI dendron) is described herein. The dendritic focal point was attached to a tetraethylene glycol spacer that was terminated with a Tmob-protected thiol in order to both avoid any side-reaction during functionalization of dendritic branches as well as enable convenient integration of the dendron into diverse complex systems. The protonation of the final PPI dendron at pH 4-5 is predicted to induce lysosomal degradation through the proton-sponge effect, and therefore enable cytosolic release. These features make the prepared dendron a very convenient building-block for use in the construction of larger systems, such as multifunctional drug delivery vehicles. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.01.070

文献信息

• Set of Highly Stable Amine- and Carboxylate-Terminated Dendronized Au Nanoparticles with Dense Coating and Nontoxic Mixed-Dendronized Form
  作者：Arunendra Saha Ray、William E. Ghann、Phoebe S. Tsoi、Brian Szychowski、Lance T. Dockery、Yewon J. Pak、Wenjing Li、Maureen A. Kane、Peter Swaan、Marie-Christine Daniel

  DOI：10.1021/acs.langmuir.8b03196

  日期：2019.3.5

  formation of a highly stable, dendronized gold nanoparticle (AuNP)-based drug delivery platform is described herein. The AuNP-based platform is composed of three complementary parts: (i) a 15 nm AuNP core, (ii) a heterofunctional thioctic acid-terminated tetraethylene glycol spacer, and (iii) a third-generation PPI dendron with a unique protonation profile and diverse end-group functionalization that allows

  本文描述了克级的新型聚（亚丙基亚胺）（PPI）树突的合成及其在形成高度稳定的，基于树突化的金纳米颗粒（AuNP）的药物递送平台中的用途。基于AuNP的平台由三个互补部分组成：（i）15 nm AuNP核，（ii）杂官能硫辛酸封端的四甘醇间隔基，以及（iii）具有独特质子化特征的第三代PPI树突和多样化的端基功能化，可以进一步衍生化。所制备的树突状AuNPs能够经受数轮冻干循环而没有聚集迹象，在磷酸盐缓冲液和汉克斯缓冲液以及血清中稳定，并且对谷胱甘肽交换反应具有抗降解性。这个纳米载体平台显示出致密的涂层，具有超过1400个树突/ AuNP，这将实现非常高的有效载荷。此外，虽然预期胺端基的AuNPs从1nM的NP浓度显示出对MCF-7乳腺癌细胞系的细胞毒性，但有趣的是，混合的单层AuNPs（涂有40/60胺/羧酸根树突）没有任何毒性迹象。浓度高达15 nM，类似于羧酸盐封端的AuNPs。所述的
• Modular and efficient synthesis of a poly (propylene imine) (PPI) dendron applied to acid-sensitive doxorubicin conjugation
  作者：Lance Dockery、Stephanie Zalesak-Kravec、Maureen A. Kane、Marie-Christine Daniel

  DOI：10.1016/j.tet.2022.133044

  日期：2022.10