(R)-ethyl-5-amino-3-(tert-butyldimethylsilyloxy)-5-oxopentanoate | 1198618-05-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (R)-ethyl-5-amino-3-(tert-butyldimethylsilyloxy)-5-oxopentanoate
• 英文别名: ethyl (3R)-5-amino-3-[tert-butyl(dimethyl)silyl]oxy-5-oxopentanoate
• CAS: 1198618-05-1
• 化学式: C₁₃H₂₇NO₄Si
• 分子量: 289.447
• InChiKey: WFQSZPFLGMWRKK-SNVBAGLBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.21
• 重原子数：
  19
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  78.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (R)-(-)-ethyl 4-cyano-3-(tert-butyldimethylsilyloxy)butyrate 在 Wilkinson's catalyst 、 乙醛肟 作用下， 以 甲苯 为溶剂， 以76%的产率得到(R)-ethyl-5-amino-3-(tert-butyldimethylsilyloxy)-5-oxopentanoate
  参考文献：
  名称：

  Anhydrous Hydration of Nitriles to Amides using Aldoximes as the Water Source

  摘要：

  Anhydrous hydrolysis of nitriles to amides was developed using acetaldoxime as the water source in the presence of Rh catalyst. Conversion of various nitriles to amides was performed under neutral and anhydrous conditions, and the reaction displays excellent compatibility with acid or base labile and hydrolytically labile functional groups.

  DOI：

  10.1021/ol902309z

文献信息

• Anhydrous Hydration of Nitriles to Amides using Aldoximes as the Water Source
  作者：Jinwoo Lee、Min Kim、Sukbok Chang、Hee-Yoon Lee

  DOI：10.1021/ol902309z

  日期：2009.12.17

  Anhydrous hydrolysis of nitriles to amides was developed using acetaldoxime as the water source in the presence of Rh catalyst. Conversion of various nitriles to amides was performed under neutral and anhydrous conditions, and the reaction displays excellent compatibility with acid or base labile and hydrolytically labile functional groups.
• Anhydrous Hydration of Nitriles to Amides: p-Carbomethoxybenzamide
  作者：Kang, Dahye、Lee, Jinwoo、Lee, Hee-Yoon

  DOI：10.15227/orgsyn.089.0066

  日期：——