10-methoxy-6-methyl-7H-benzo[d][1,2]benzothiazepine 5,5-dioxide | 1153687-26-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 10-methoxy-6-methyl-7H-benzo[d][1,2]benzothiazepine 5,5-dioxide
• CAS: 1153687-26-3
• 化学式: C₁₅H₁₅NO₃S
• 分子量: 289.355
• InChiKey: JCRCHZGSZDOYSA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  55
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-bromo-N-methylbenzenesulfonamide 在 palladium diacetate 、 caesium carbonate 、 三苯基膦 作用下， 以 甲苯 为溶剂， 反应 24.0h， 以56%的产率得到10-methoxy-6-methyl-7H-benzo[d][1,2]benzothiazepine 5,5-dioxide
  参考文献：
  名称：

  α-Haloarylsulfonamides: multiple cyclization pathways to skeletally diverse benzofused sultams

  摘要：

  The development of new methods to skeletally diverse sultams based oil a central alpha-halo benzene sulfonamide building block is reported. Several salient features of this building block are Utilized ill multiple reaction pathways, including the Fleck reaction, C- and O-arylation, Sonogashira-Pauson-Khand, Sonogashira-intramolecular hydroamination, and domino aza-Michael-Heck for the generation of five-, six-, and seven-membered benzofused bicyclic and tricyclic sultams. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.11.053

文献信息

• α-Haloarylsulfonamides: multiple cyclization pathways to skeletally diverse benzofused sultams
  作者：Dinesh Kumar Rayabarapu、Aihua Zhou、Kyu Ok Jeon、Thiwanka Samarakoon、Alan Rolfe、Hina Siddiqui、Paul R. Hanson

  DOI：10.1016/j.tet.2008.11.053

  日期：2009.4

  The development of new methods to skeletally diverse sultams based oil a central alpha-halo benzene sulfonamide building block is reported. Several salient features of this building block are Utilized ill multiple reaction pathways, including the Fleck reaction, C- and O-arylation, Sonogashira-Pauson-Khand, Sonogashira-intramolecular hydroamination, and domino aza-Michael-Heck for the generation of five-, six-, and seven-membered benzofused bicyclic and tricyclic sultams. (C) 2008 Elsevier Ltd. All rights reserved.