{7-[5-(2,4-difluorobenzyl)-1H-1,2,3-triazoI-1-yl]-4-fluoro-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl}acetic acid | 1242273-33-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: {7-[5-(2,4-difluorobenzyl)-1H-1,2,3-triazoI-1-yl]-4-fluoro-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl}acetic acid
• 英文别名: 2-[7-[5-[(2,4-Difluorophenyl)methyl]triazol-1-yl]-4-fluoro-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]acetic acid
• CAS: 1242273-33-1
• 化学式: C₂₃H₁₉F₃N₄O₂
• 分子量: 440.425
• InChiKey: LLPLNLKJLNWGLT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  72.9
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• INDOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS
  申请人：Berthelette Carl

  公开号：US20100234415A1

  公开（公告）日：2010-09-16

  Compound of formula I are antagonists of the PGD2 receptor, CRTH2, and as such are useful in the treatment and/or prevention of CRTH2-mediated diseases such as asthma.

  公式I的化合物是PGD2受体CRTH2的拮抗剂，因此在治疗和/或预防CRTH2介导的疾病，如哮喘方面是有用的。
• Indole Derivatives as CRTH2 Receptor Antagonists
  申请人：Berthelette Carl

  公开号：US20130150398A1

  公开（公告）日：2013-06-13

  Compound of formula I are antagonists of the PGD2 receptor, CRTH2, and as such are useful in the treatment and/or prevention of CRTH2-mediated diseases such as asthma.

  公式I的化合物是PGD2受体CRTH2的拮抗剂，因此可用于治疗和/或预防CRTH2介导的疾病，如哮喘。
• Indole derivatives as CRTH2 receptor antagonists in combination with a second active ingredient
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP2492267A1

  公开（公告）日：2012-08-29

  Compound of formula I are antagonists of the PGD2 receptor, CRTH2, and as such are useful in the treatment and/or prevention of CRTH2-mediated diseases such as asthma in combination with a second active ingredient such as a leukotriene antagonist.

  式 I 的化合物是 PGD2 受体 CRTH2 的拮抗剂，因此可与第二种活性成分（如白三烯拮抗剂）联合用于治疗和/或预防 CRTH2 介导的疾病，如哮喘。
• US8394819B2
  申请人：——

  公开号：US8394819B2

  公开（公告）日：2013-03-12
• US9023864B2
  申请人：——

  公开号：US9023864B2

  公开（公告）日：2015-05-05