1-[2,2-Dibutyl-5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadiazol-3-yl]ethanone | 1071432-94-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-[2,2-Dibutyl-5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadiazol-3-yl]ethanone
• CAS: 1071432-94-4
• 化学式: C₂₁H₃₂N₂O₅
• 分子量: 392.495
• InChiKey: KWMHDCJWYIPXON-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  28
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  69.6
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3,4,5-trimethoxy-N'-(nonan-5-ylidene)benzohydrazide 、 乙酸酐 以86%的产率得到1-[2,2-Dibutyl-5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadiazol-3-yl]ethanone
  参考文献：
  名称：

  1,3,4-Oxadiazole-3(2H)-carboxamide derivatives as potential novel class of monoamine oxidase (MAO) inhibitors: Synthesis, evaluation, and role of urea moiety

  摘要：

  A new series of 1,3,4-oxadiazole-3(2H)-carboxamide derivatives have been synthesized by direct heterocyclization reaction of substituted benzoylisocyanate with various aroylhydrazones as novel monoamine oxidase inhibitors (MAOIs). The target molecules have been identified on the basis of satisfactory analytical and spectra ( IR, (1)H NMR, (13)C NMR, and HR-MS) data. The newly synthesized compounds were evaluated for their MAO inhibitory activity by kynuramine fluorimetric assay method. The preliminary results showed that most of the compounds have moderate inhibitory activities toward MAO at the concentration of 10(5)-10(3) M. This work may provide a novel class of lead compounds with potential MAO inhibitions for further optimization. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.07.026

文献信息

• 1,3,4-Oxadiazole-3(2H)-carboxamide derivatives as potential novel class of monoamine oxidase (MAO) inhibitors: Synthesis, evaluation, and role of urea moiety
  作者：Shaoyong Ke、Zhong Li、Xuhong Qian

  DOI：10.1016/j.bmc.2008.07.026

  日期：2008.8

  A new series of 1,3,4-oxadiazole-3(2H)-carboxamide derivatives have been synthesized by direct heterocyclization reaction of substituted benzoylisocyanate with various aroylhydrazones as novel monoamine oxidase inhibitors (MAOIs). The target molecules have been identified on the basis of satisfactory analytical and spectra ( IR, (1)H NMR, (13)C NMR, and HR-MS) data. The newly synthesized compounds were evaluated for their MAO inhibitory activity by kynuramine fluorimetric assay method. The preliminary results showed that most of the compounds have moderate inhibitory activities toward MAO at the concentration of 10(5)-10(3) M. This work may provide a novel class of lead compounds with potential MAO inhibitions for further optimization. (C) 2008 Elsevier Ltd. All rights reserved.
• 1,3,4-Oxadiazoline derivatives as novel potential inhibitors targeting chitin biosynthesis: Design, synthesis and biological evaluation
  作者：Shaoyong Ke、Fengyi Liu、Ni Wang、Qing Yang、Xuhong Qian

  DOI：10.1016/j.bmcl.2008.11.095

  日期：2009.1

  Two series of 1,3,4-oxadiazoline heterocycle derivatives were designed, synthesized and identified. Bioactivity assays showed that all synthesized compounds inhibited chitin synthesis in yeast, suggesting they might be a novel class of potential inhibitors against chitin biosynthesis. The structure-activity relationships (SAR) of these compounds are discussed. (C) 2008 Elsevier Ltd. All rights reserved.