H-Gly-Lys(Boc)-OMe | 924885-05-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: H-Gly-Lys(Boc)-OMe
• 英文别名: HGlyLys(Boc)OMe
• CAS: 924885-05-2
• 化学式: C₁₄H₂₇N₃O₅
• 分子量: 317.385
• InChiKey: RDMDTQZJSUFACJ-JTQLQIEISA-N

物化性质

• 沸点：
  497.6±45.0 °C(Predicted)
• 密度：
  1.111±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  22.0
• 可旋转键数：
  8.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  119.75
• 氢给体数：
  3.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  H-Gly-Lys(Boc)-OMe 在 三(2-氨基乙基)胺 、 碳酸氢钠 作用下， 以 二氯甲烷 为溶剂， 生成 FmocGlyLeuGlyLys(Boc)OMe
  参考文献：
  名称：

  Transglutaminase surface recognition by peptidocalix[4]arene diversomers

  摘要：

  A series of N-linked tetrakis(tetrapeptido)calix[4]arene diversomers, 3A-P, has been synthesized by Coupling of a cone calix[4]arene tetracarboxylic acid chloride with tetrapeptides 1A-P obtained in a parallel fashion. The inhibition activity of 3A-P towards tissue and microbial transglutaminase was evaluated by in vitro assays with a labeled substrate. Kinetic analysis using one of the most active derivatives (3A) showed a noncompetitive inhibition with respect to the amino acceptor Substrate and an uncompetitive inhibition with respect to amino donor substrate. Experimental results are in accordance with ail inhibition due to a protein specific surface recognition on a region noncomprising the enzyme active site. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.01.078
• 作为产物：
  描述：

  (S)-methyl 2-amino-6-(tert-butoxycarbonylamino)hexanoate 在 三(2-氨基乙基)胺 、 碳酸氢钠 作用下， 以 二氯甲烷 为溶剂， 生成 H-Gly-Lys(Boc)-OMe
  参考文献：
  名称：

  Transglutaminase surface recognition by peptidocalix[4]arene diversomers

  摘要：

  A series of N-linked tetrakis(tetrapeptido)calix[4]arene diversomers, 3A-P, has been synthesized by Coupling of a cone calix[4]arene tetracarboxylic acid chloride with tetrapeptides 1A-P obtained in a parallel fashion. The inhibition activity of 3A-P towards tissue and microbial transglutaminase was evaluated by in vitro assays with a labeled substrate. Kinetic analysis using one of the most active derivatives (3A) showed a noncompetitive inhibition with respect to the amino acceptor Substrate and an uncompetitive inhibition with respect to amino donor substrate. Experimental results are in accordance with ail inhibition due to a protein specific surface recognition on a region noncomprising the enzyme active site. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.01.078

文献信息

• Utilizing Reversible Copper(II) Peptide Coordination in a Sequence-Selective Luminescent Receptor
  作者：Stefan Stadlbauer、Alexander Riechers、Andreas Späth、Burkhard König

  DOI：10.1002/chem.200701442

  日期：2008.3.7

  The benzocrown ether recognizes the N-terminal amino moiety intramolecularly, and the significantly increased emission intensity signals the binding event, because only if prior coordination of the peptide has taken place is the intramolecular ammonium ion-benzocrown ether interaction of sufficient strength in water to trigger an emission signal. Intermolecular ammonium ion-benzocrown ether binding

  尽管可以获得有关氨基酸和肽与金属离子的配位能力的大量信息，但在选择性肽受体的合理设计中很少使用这种信息。我们将铜（II）次氮基三乙酸根（NTA）配合物与对铵离子敏感的发光苯并冠醚结合在一起。该化合物显示了对含甘氨酸和组氨酸的序列的微摩尔亲和力和选择性，与铜（II）离子肽结合的序列非常相似：铜（II）NTA络合物的两个自由配位点与咪唑和氨基氮原子结合，复制非复合铜离子的初始配位步骤。苯并冠醚在分子内识别N端氨基部分，并且发射强度的显着增加表明结合事件，因为只有在事先进行了肽的配位后，分子内的铵离子-苯并冠醚之间的相互作用才能在水中产生足够的强度，从而触发发射信号。没有观察到分子间铵离子-苯并冠醚的结合。等温滴定热量法证实了从发射滴定得出的结合常数。因此，如从肽配位研究中推论出的，截短的铜（II）配位球和发光的苯并冠状醚的组合可以更合理地设计序列选择性肽受体。等温滴定热量法证实了从发射滴定得出