2-(methoxymethoxy)-5-(methoxy)benzeneboronic acid | 1258154-18-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-(methoxymethoxy)-5-(methoxy)benzeneboronic acid
• 英文别名: 2-(methoxymethoxy)-5-(methoxy)phenylboronic acid；B-[5-Methoxy-2-(methoxymethoxy)phenyl]boronic acid；[5-methoxy-2-(methoxymethoxy)phenyl]boronic acid
• CAS: 1258154-18-5
• 化学式: C₉H₁₃BO₅
• 分子量: 212.01
• InChiKey: XWNOGBTWAOKRJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.64
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  68.2
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-(methoxymethoxy)-5-(methoxy)benzeneboronic acid 、 4-bromo-N,N-bis[2-[2-(2-methoxyethoxy)ethoxy]ethyl]aniline 在 四(三苯基膦)钯 、 碳酸氢钠 作用下， 以 水 、 甲苯 为溶剂， 反应 24.0h， 生成
  参考文献：
  名称：

  A highly selective naked-eye probe for hypochlorite with the p-methoxyphenol-substituted aniline compound

  摘要：

  A highly selective naked-eye detection of CIO- is successfully established with probe 1 by taking advantage of the oxidation transformation of p-methoxyphenol into benzoquinone with CIO- and the ICT absorption within the electron donor-acceptor compound. The color of the solution of probe 1 was changed, obviously upon addition of CIO- and CIO- with concentration as low as 1.74 mu M can be analyzed in aqueous solution with probe 1. Moreover, the interferences of other anions can be neglected. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.09.041
• 作为产物：
  描述：

  在 水 、 氯化铵 作用下， 以 四氢呋喃 为溶剂， 以2.51 g的产率得到2-(methoxymethoxy)-5-(methoxy)benzeneboronic acid
  参考文献：
  名称：

  A highly selective naked-eye probe for hypochlorite with the p-methoxyphenol-substituted aniline compound

  摘要：

  A highly selective naked-eye detection of CIO- is successfully established with probe 1 by taking advantage of the oxidation transformation of p-methoxyphenol into benzoquinone with CIO- and the ICT absorption within the electron donor-acceptor compound. The color of the solution of probe 1 was changed, obviously upon addition of CIO- and CIO- with concentration as low as 1.74 mu M can be analyzed in aqueous solution with probe 1. Moreover, the interferences of other anions can be neglected. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.09.041

文献信息

• Rhodium(<scp>ii</scp>)-catalyzed C–H carboxylation of ferrocenes with CO₂
  作者：Hong Lv、Xinchao Wang、Yanzhao Hao、Chao Ma、Shangda Li、Gang Li、Jian Zhang

  DOI：10.1039/d2gc04337h

  日期：——

  remains challenging. Herein, a protocol for Rh(II)-catalyzed and CO2-involved carboxylation of inert sp2 C–H bonds from the cyclopentadienyl (Cp) ring of ferrocene derivatives was reported, which produces a series of ferrocene-embedded lactones that are important molecular skeletons widely used in pharmaceuticals or ligands. Moreover, moderate enantioselectivity was achieved with a chiral NHC ligand, which

  二氧化碳 (CO 2 ) 被认为是绿色和可再生的 C1 原料。然而，由于其热力学和动力学稳定性，过渡金属催化未活化的 C-H 键与 CO 2的羧化反应仍然具有挑战性。在此，报道了 Rh( II ) 催化和 CO 2参与的二茂铁衍生物环戊二烯基 (Cp) 环惰性 sp 2 C-H 键羧化反应的方案，该方案产生了一系列重要的二茂铁嵌入内酯广泛用于药物或配体的分子骨架。此外，使用手性 NHC 配体实现了适度的对映选择性，这可以被视为与 CO 2进行不对称 C-H 羧化的第一个例子. 初步的机理实验支持二价铑作为真正的活性催化剂，并据此提出了合理的催化循环。