2-(Benzylamino)-2-(2-chloro-8-methylquinolin-3-yl)acetamide | 1421699-25-3

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 2-(Benzylamino)-2-(2-chloro-8-methylquinolin-3-yl)acetamide
• CAS: 1421699-25-3
• 化学式: C₁₉H₁₈ClN₃O
• 分子量: 339.824
• InChiKey: STWSXFANZHAMGO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  68
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(Benzylamino)-2-(2-chloro-8-methylquinolin-3-yl)acetamide 在 盐酸 、 氢气 、 palladium(II) hydroxide 作用下， 生成 methyl 2-amino-2-(8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)acetate hydrochloride
  参考文献：
  名称：

  Efficient synthesis and X-ray structures of new α-quinolin-3-yl-α-aminonitriles and derivatives

  摘要：

  This study describes the synthesis of novel alpha-aminonitrile derivatives possessing a quinoline subunit via a Strecker reaction. Chiral alpha-methylbenzylamines were used to carry out the diastereoselective version of this sequence. Conversion of an enantiopure 2-chloroquinolin-3-yl derivative into the corresponding alpha-aminoester resulted in the concomitant formation of a 2(1H)-quinolinone moiety and a partial racemization. Single crystal X-ray structures are reported for three compounds. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.11.032
• 作为产物：
  描述：

  2-(Benzylamino)-2-(2-chloro-8-methylquinolin-3-yl)acetonitrile 在 硫酸 作用下， 以 二氯甲烷 为溶剂， 以75%的产率得到2-(Benzylamino)-2-(2-chloro-8-methylquinolin-3-yl)acetamide
  参考文献：
  名称：

  Efficient synthesis and X-ray structures of new α-quinolin-3-yl-α-aminonitriles and derivatives

  摘要：

  This study describes the synthesis of novel alpha-aminonitrile derivatives possessing a quinoline subunit via a Strecker reaction. Chiral alpha-methylbenzylamines were used to carry out the diastereoselective version of this sequence. Conversion of an enantiopure 2-chloroquinolin-3-yl derivative into the corresponding alpha-aminoester resulted in the concomitant formation of a 2(1H)-quinolinone moiety and a partial racemization. Single crystal X-ray structures are reported for three compounds. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.11.032