The total synthesis of the 18-membered lichen macrolide, (+)-aspicilin, has been accomplished utilizing the Swem oxidation, Masamune-Roush olefination, and ring-closing metathesis of a trienic ester as key steps. D-Mannitol has been utilized as the chiral pool material for the construction of the olefinic aldehyde and the Jacobsen hydrolytic kinetic resolution has been employed for the construction
Asymmetric Synthesis of Saturated and Unsaturated Hydroxy Fatty Acids (HFAs) and Study of Their Antiproliferative Activity
作者:Olga G. Mountanea、Christiana Mantzourani、Dimitrios Gkikas、Panagiotis K. Politis、George Kokotos
DOI:10.3390/biom14010110
日期:——
regioisomers of (R)- and (S)-hydroxypalmitic acids (HPAs) and hydroxystearic acids (HSAs), whose biological activity has not been tested so far, were studied for their antiproliferative activities. The unsaturation of the long chain, as well as an odd-numbered (C17) fattyacidchain, led to reduced activity, while the new 6-(S)-HPA regioisomer was identified as exhibiting potent antiproliferative activity