N2,N2-二乙基-5-硝基嘧啶-2,4-二胺 | 856973-04-1

• 分子结构分类: 有机化合物 - 有机1,3-偶极化合物 - 烯丙基型1,3-偶极有机化合物
• 中文名称: N2,N2-二乙基-5-硝基嘧啶-2,4-二胺
• 英文名称: N²,N²-diethyl-5-nitro-pyrimidine-2,4-diyldiamine
• 英文别名: N²,N²-Diaethyl-5-nitro-pyrimidin-2,4-diyldiamin；N2,N2-diethyl-5-nitropyrimidine-2,4-diamine；2-N,2-N-diethyl-5-nitropyrimidine-2,4-diamine
• CAS: 856973-04-1
• 化学式: C₈H₁₃N₅O₂
• 分子量: 211.224
• InChiKey: NYFSXBVXJYHCQE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  101
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N2,N2-二乙基-5-硝基嘧啶-2,4-二胺 在 甲醇 、 镍 作用下， 生成 N-(4-amino-2-diethylamino-pyrimidin-5-yl)-formamide
  参考文献：
  名称：

  Purines. II. The Synthesis of Certain Purines and the Cyclization of Several Substituted 4,5-Diaminopyrimidines¹

  摘要：

  DOI：

  10.1021/ja01098a003
• 作为产物：
  描述：

  2-氯-4-氨基-5-硝基嘧啶 、 二乙胺 在 1,4-二氧六环 作用下， 生成 N2,N2-二乙基-5-硝基嘧啶-2,4-二胺
  参考文献：
  名称：

  Hypertension in Older Adults

  摘要：

  The high prevalence of hypertension in older persons (nearly one of two subjects aged 60 years and older) suggests that the recognition and treatment should he a priority fur physicians. Although diastolic blood pressure is regarded as an important risk factor, it is now clear that isolated systolic hypertension and elevated pulse pressure also play an important role in the development of cerebrovascular disease, congestive heart failure, and coronary heart disease, which are the major causes of cardiovascular morbidity and mortality in the population aged older than 65 years. Controlled, randomized trials have shown that treatment of systolic as well as systolodiastolic hypertension decreases the incidence of cardiovascular and cerebrovascular complications in older adults. The question of whether treatment of hypertension should be maintained in very old persons, those older than 80 years, is still undecided.

  DOI：

  10.1093/gerona/56.4.m217