17-allyl-4,5-epoxy-morphinane-3,14-diol | 103369-94-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: 17-allyl-4,5-epoxy-morphinane-3,14-diol
• 英文别名: 3-Prop-2-enyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diol
• CAS: 103369-94-4
• 化学式: C₁₉H₂₃NO₃
• 分子量: 313.397
• InChiKey: BOKMZCWMDBIKAI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  52.9
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• CHEMICALLY MODIFIED SMALL MOLECULES
  申请人：Nektar Therapeutics

  公开号：US20170095565A1

  公开（公告）日：2017-04-06

  Methods of modifying the rate of systemic absorption of a drug administered to a subject by a pulmonary route, the method comprising covalently conjugating a hydrophilic polymer to a drug, wherein the drug has a half-life of elimination from the lung of less than about 180 minutes, to form a drug-polymer conjugate, wherein the drug-polymer conjugate has a net hydrophilic character and a weight average molecular weight of from about 50 to about 20,000 Daltons, and wherein the half-life of elimination from the lung of the drug-polymer conjugate is at least about 1.5-fold greater than the half-life of elimination from the lung of the drug, wherein the half-life of elimination from the lung is measured by bronchoalveolar lavage followed by assaying residual lung material.