2-[4-(Furan-2-yl)-1-phenyl-5-propylpyrrol-2-yl]-1-methylbenzimidazole | 1194953-60-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 2-[4-(Furan-2-yl)-1-phenyl-5-propylpyrrol-2-yl]-1-methylbenzimidazole
• CAS: 1194953-60-0
• 化学式: C₂₅H₂₃N₃O
• 分子量: 381.477
• InChiKey: SEUXQWPFLUOCPS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  35.9
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-(Furan-2-yl)-1-(1-methylbenzimidazol-2-yl)heptane-1,4-dione 、 苯胺 在 溶剂黄146 作用下， 以 甲醇 为溶剂， 生成 2-[4-(Furan-2-yl)-1-phenyl-5-propylpyrrol-2-yl]-1-methylbenzimidazole
  参考文献：
  名称：

  Organic Catalytic Multicomponent One-Pot Synthesis of Highly Substituted Pyrroles

  摘要：

  A multicomponent synthesis of highly substituted pyrroles catalyzed by thiazolium salts has been disclosed. The reaction employs an acyl anion conjugate addition reaction of aldegyde and unsaturated ketones to generate 1,4-dicarbonyl compounds in situ. The subsequent addition of various amines promotes a Paal-Knorr reaction, affording the desired pyrrole nucleus in an efficient one-pot process.

  DOI：

  10.1080/00397910902838953

文献信息

• Organic Catalytic Multicomponent One-Pot Synthesis of Highly Substituted Pyrroles
  作者：Xiaobi Jing、Xin Pan、Zhen Li、Xiaoxin Bi、Chaoguo Yan、Hongxiang Zhu

  DOI：10.1080/00397910902838953

  日期：2009.10.12

  A multicomponent synthesis of highly substituted pyrroles catalyzed by thiazolium salts has been disclosed. The reaction employs an acyl anion conjugate addition reaction of aldegyde and unsaturated ketones to generate 1,4-dicarbonyl compounds in situ. The subsequent addition of various amines promotes a Paal-Knorr reaction, affording the desired pyrrole nucleus in an efficient one-pot process.