Oxybate carnitine | 107870-81-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Oxybate carnitine
• 英文别名: (3R)-3-(4-hydroxybutanoyloxy)-4-(trimethylazaniumyl)butanoate
• CAS: 107870-81-5
• 化学式: C11H21NO5
• 分子量: 247.29
• InChiKey: ZFJOZGQNTJRPDE-SECBINFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  86.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Use of esters of acyl L-carnitines with gamma-hydroxybutyric acid for producing pharmaceutical compositions for the treatment of hepatopathies
  申请人：Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.

  公开号：EP0514357A1

  公开（公告）日：1992-11-19

  Esters of acyl L-carnitine with gamma-hydroxybutyric acid, both as pharmacologically acceptable salts of formula (1) and as inner salts of formula (1') wherein X⁻ is the anion of a pharmacologically acceptable acid and R is a straight or branched acyl group having from 2 to 5 carbon atoms, are used for producing pharmaceutical compositions effective for treating hepatopathies.

  酰基 L-肉碱与γ-羟基丁酸的酯，两者均为药理上可接受的式 (1) 盐 和式 (1') 的内盐 其中 X- 是药理学上可接受的酸的阴离子，R 是具有 2 至 5 个碳原子的直链或支链酰基，用于生产治疗肝病的药物组合物。
• Use of acyl L-carnitine gamma-hydroxybutyrate for the treatment of alcoholism
  申请人：Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.

  公开号：EP0616805A1

  公开（公告）日：1994-09-28

  The use of acyl L-carnitine esters with gamma-hydroxybutyric acid is described of the formula wherein R is straight or branched acyl with from 2 to 5 carbon atoms, preferably acetyl, propionyl, n-butyryl, isobutyryl and isovaleryl, and X is the anion of a pharmacologically acceptable acid or of the corresponding inner salts to produce a drug to suppress withdrawal symptoms and craving for alcohol in alcoholics.

  描述了含有γ-羟基丁酸的酰基左旋肉碱酯的使用方法，其分子式为 其中 R 是具有 2 至 5 个碳原子的直链或支链酰基，最好是乙酰基、丙酰基、正 丁酰基、异丁酰基和异戊酰基，X 是药理学上可接受的酸或相应内盐的阴离子，用于生产抑制酗酒者戒酒症状和对酒精的渴望的药物。
• Use of acyl L-carnitine gamma-hydroxybutyrate for the treatment of drug addiction
  申请人：Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.

  公开号：EP0630648A1

  公开（公告）日：1994-12-28

  The use of acyl L-carnitine esters with gamma-hydroxybutyric acid is described in which the acyl is preferably acetyl, propionyl, n-butyryl, isobutyryl, valeryl or isovaleryl to produce a drug to suppress withdrawal symptoms and the craving for self-administration of narcotic substances in drug addicts.

  描述了酰基左旋肉碱酯与γ-羟基丁酸的用途，其中酰基最好是乙酰基、丙酰基、正丁酰基、异丁酰基、戊酰基或异戊酰基，用于生产一种药物，抑制吸毒者的戒断症状和对自我服用麻醉药物的渴望。
• Use of acyl L-carnitine gamma-hydroxybutyrate for the manufacture of a medicamentfor the treatment of drug addiction
  申请人：Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.

  公开号：EP0630648B1

  公开（公告）日：1998-01-07
• US4415589A
  申请人：——

  公开号：US4415589A

  公开（公告）日：1983-11-15