10-methoxy-7-(4-methylphenyl)-7,12-dihydrobenzo[b]indeno[1,2-e][1,4]diazepine-5,6-dione | 1189165-31-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 10-methoxy-7-(4-methylphenyl)-7,12-dihydrobenzo[b]indeno[1,2-e][1,4]diazepine-5,6-dione
• 英文别名: 7-methoxy-10-(4-methylphenyl)-5H-indeno[2,1-c][1,5]benzodiazepine-11,12-dione
• CAS: 1189165-31-8
• 化学式: C₂₄H₁₈N₂O₃
• 分子量: 382.419
• InChiKey: AOGCICBIFSYSOC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  29
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  58.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-[(4-methylphenyl)amino]-N-(4-methylphenyl)-1-oxo-1H-indene-2-carboxamide 在 [双(三氟乙酰氧基)碘]苯 作用下， 以 二氯甲烷 为溶剂， 以35%的产率得到10-methoxy-7-(4-methylphenyl)-7,12-dihydrobenzo[b]indeno[1,2-e][1,4]diazepine-5,6-dione
  参考文献：
  名称：

  A Convenient Approach to Fused Indeno-1,4-diazepinones through Hypervalent Iodine Chemistry

  摘要：

  Indenocarboxamides, resulting from the sequential addition of two arylamine equivalents to indanedione ketene dimer, are oxidized by [bis(trifluoroacetoxy)iodobenzene] to fused indeno-1,4-diazepinones in yields depending on the substituents on both aromatic rings. A plausible reaction pathway explaining the formation of the title compounds, as well as the formation of the two other minor products of the reaction, through a common intermediate, is suggested.

  DOI：

  10.1021/jo9013063

文献信息

• A Convenient Approach to Fused Indeno-1,4-diazepinones through Hypervalent Iodine Chemistry
  作者：Elizabeth Malamidou-Xenikaki、Spyros Spyroudis、Maria Tsanakopoulou、Dimitra Hadjipavlou-Litina

  DOI：10.1021/jo9013063

  日期：2009.10.2

  Indenocarboxamides, resulting from the sequential addition of two arylamine equivalents to indanedione ketene dimer, are oxidized by [bis(trifluoroacetoxy)iodobenzene] to fused indeno-1,4-diazepinones in yields depending on the substituents on both aromatic rings. A plausible reaction pathway explaining the formation of the title compounds, as well as the formation of the two other minor products of the reaction, through a common intermediate, is suggested.