4-(1α,5α,6α-bicyclo[3.1.0]hex-6-yl)-morpholine | 83328-01-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 4-(1α,5α,6α-bicyclo[3.1.0]hex-6-yl)-morpholine
• CAS: 83328-01-2
• 化学式: C₁₀H₁₇NO
• 分子量: 167.251
• InChiKey: AMMPSEXPBUKHDN-MYJAWHEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.12
• 重原子数：
  12.0
• 可旋转键数：
  1.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12.47
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  1α,5α,6α-1-chloro-6-morpholino-bicyclo[3.1.0]hexane-6-carbonitrile 在 氨 、 sodium 作用下， 以72%的产率得到4-(1α,5α,6α-bicyclo[3.1.0]hex-6-yl)-morpholine
  参考文献：
  名称：

  Reductive Decyanation of Annulated Aminocyclopropane-endo-carbonitriles - a way to annulated cyclopropane-exo-amines

  摘要：

  Annulated Aminocyclopropane-endo-carbonitriles 11a,b are reductively decyanated by sodium in liquid ammonia with complete retention of configuration. An additionally existing chlorine atom in the starting materials 12a,c-e, thereby, is simultaneously replaced by hydrogen. The preparative advantage of this method is demonstrated by the selective access to 6 alpha-H-isomers 13b and 13e as members of the ensemble of bicyclo[3.1.0]hexanediyl-dimorpholine diastereomers. A strong buckled bicyclohexane unit is present in 3 alpha,6 alpha-isomer 13e as indicated by H-1 NMR spectroscopy and X-ray structural analysis.

  DOI：

  10.1002/prac.19983400410

文献信息

• Vilsmaier, Elmar; Klein, Claus Michael; Troeger, Wolfgang, Chemische Berichte, 1982, vol. 115, # 8, p. 2795 - 2806
  作者：Vilsmaier, Elmar、Klein, Claus Michael、Troeger, Wolfgang

  DOI：——

  日期：——
• VILSMAIER, E.;KLEIN, C. M.;TROEGER, W., CHEM. BER., 1982, 115, N 8, 2795-2806
  作者：VILSMAIER, E.、KLEIN, C. M.、TROEGER, W.

  DOI：——

  日期：——