(Z)-2-(4,5-dihydro-1,3-oxazol-2-yl)-1-(4-methoxyphenyl)-1-ethen-1-amine | 221907-01-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (Z)-2-(4,5-dihydro-1,3-oxazol-2-yl)-1-(4-methoxyphenyl)-1-ethen-1-amine
• 英文别名: (Z)-2-(4,5-dihydro-1,3-oxazol-2-yl)-1-(4-methoxyphenyl)-1-ethenylamine；(Z)-2-(4,5-dihydro-1,3-oxazol-2-yl)-1-(4-methoxyphenyl)ethenamine
• CAS: 221907-01-3
• 化学式: C₁₂H₁₄N₂O₂
• 分子量: 218.255
• InChiKey: FZNCTUBEGMZDDP-FLIBITNWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  56.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (Z)-2-(4,5-dihydro-1,3-oxazol-2-yl)-1-(4-methoxyphenyl)-1-ethen-1-amine 在 盐酸 、 sodium 、 叔丁醇 作用下， 以 四氢呋喃 为溶剂， 生成 3-氨基-3-(4-甲氧基苯基)丙酸
  参考文献：
  名称：

  A new and expeditious strategy for the synthesis of β-amino acids from Δ2-oxazolines

  摘要：

  A new, mild two-step synthesis of racemic p-amino acids starting from 2-allkyl-Delta (2)-oxazolines is described. The process implies the initial formation of masked N-substituted or N-unsubstituted beta -enamino acid derivatives followed by chemoselective reduction of the enamino moiety. The process takes place with high yields, total chemoselectivity and moderate diastereoselectivity. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(00)01056-5
• 作为产物：
  描述：

  2-甲基-2-恶唑啉 、 4-甲氧基苯甲腈 在 lithium diisopropyl amide 作用下， 生成 (Z)-2-(4,5-dihydro-1,3-oxazol-2-yl)-1-(4-methoxyphenyl)-1-ethen-1-amine
  参考文献：
  名称：

  Synthesis and C-alkylation of C-protected β-enamino acid derivatives from oxa- thia- and imidazolines

  摘要：

  Various heterocycles 3a-h can be readily metallated and condensed with a variety of organic nitriles to afford C-protected beta-enamino acid derivatives 1 (or 2). Procedures for alkylation of compounds 1 to obtain 2 as well as a "one-pot" preparation of 2 from 3 are also described. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(99)00042-3

文献信息

• A new and mild synthesis of β-amino acids from masked β-enamino acid derivatives
  作者：Santos Fustero、Ma Dolores Díaz、Antonio Navarro、Esther Salavert、Enrique Aguilar

  DOI：10.1016/s0040-4039(98)02469-1

  日期：1999.1

  A new method of synthesis of racemic β-amino acids 6 by reduction of masked N-substituted and N-unsubstituted β-enamino acid derivatives 4via C-protected β-amino acids 5 is described. The process occurs with high yields, total chemoselectivity and moderate diastereoselectivity. Readily available starting materials, inexpensive reagents and mild conditions are used to furnish derivatives 5 and 6.

  描述了一种新的合成外消旋β-氨基酸6的方法，该方法通过经由C-保护的β-氨基酸5还原被掩蔽的N-取代的和N-未取代的β-烯酸衍生物4。该过程以高收率，总化学选择性和中等非对映选择性发生。容易获得的起始原料，廉价的试剂和温和的条件用于提供衍生物5和6。
• An efficient synthesis of uracil derivatives from 2-alkyl-Δ2-oxazolines and nitriles
  作者：Santos Fustero、Juan F. Sanz-Cervera、Salvador Mérida、Raquel Román、Salvador Villanova、Carmen Ramírez de Arellano

  DOI：10.1016/j.jfluchem.2008.04.004

  日期：2008.9

  An efficient a rid convenient synthesis of new fluorinated a rid non-fluorinated uracils is described herein. The condensation of nitriles with enolates generated from 2-alkyl-Delta(2)-oxazolines affords fluorinated beta-enamino acid derivatives, which react with triphosgene to give an isomeric mixture of oxazolopyrimidinones. These can then be easily transformed into a single C-6 pyrimidindione derivative through reaction with a suitable nucleophile. (c) 2008 Elsevier B.V. All rights reserved.