(S)-4-(2-(benzyloxycarbonyl)-3-(4-(4-fluorobenzoyl)piperazin-1-yl)-3-oxopropyl)phenyl 4-methylbenzenesulfonate | 1011469-52-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-4-(2-(benzyloxycarbonyl)-3-(4-(4-fluorobenzoyl)piperazin-1-yl)-3-oxopropyl)phenyl 4-methylbenzenesulfonate
• 英文别名: [4-[(2S)-3-[4-(4-fluorobenzoyl)piperazin-1-yl]-3-oxo-2-(phenylmethoxycarbonylamino)propyl]phenyl] 4-methylbenzenesulfonate
• CAS: 1011469-52-5
• 化学式: C₃₅H₃₄FN₃O₇S
• 分子量: 659.735
• InChiKey: HVZWUFQIJLUSFN-YTTGMZPUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  47
• 可旋转键数：
  11
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  131
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  benzyl (S)-(1-(4-(4-fluorobenzoyl)piperazin-1-yl)-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)carbamate 、 对甲苯磺酰氯 在 4-二甲氨基吡啶 作用下， 以 二氯甲烷 为溶剂， 生成 (S)-4-(2-(benzyloxycarbonyl)-3-(4-(4-fluorobenzoyl)piperazin-1-yl)-3-oxopropyl)phenyl 4-methylbenzenesulfonate
  参考文献：
  名称：

  Synthesis and structure–activity relationship studies of tyrosine-based antagonists at the human P2X7 receptor

  摘要：

  Analogues of the P2X(7) receptor antagonist KN-62, modified at the piperazine and arylsulfonyl groups, were synthesized and assayed at the human P2X(7) receptor for inhibition of BzATP-induced effects, that is, uptake of a fluorescent dye (ethidium bromide) in stably transfected HEK293 cells and IL-1 beta release in differentiated THP-1 cells. Substitution of the arylsulfonyl, moiety with a nitro group increased antagonistic potency relative to methyl substitution, such that compound 21 was slightly more potent than KN-62. Substitution with D-tyrosine in 36 and sterically bulky tyrosyl 3,5-dimethyl groups in 9 enhanced antagonistic potency. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.11.077