11-{[4-(4-Benzyloxycarbonylaminobutyl)piperazine-1-yl]acetyl}-5,11-dihydro-6H-pyrido[2,3-b]-[1,4]benzodiazepine-6-one | 1136218-73-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 11-{[4-(4-Benzyloxycarbonylaminobutyl)piperazine-1-yl]acetyl}-5,11-dihydro-6H-pyrido[2,3-b]-[1,4]benzodiazepine-6-one
• 英文别名: benzyl N-[4-[4-[2-oxo-2-(6-oxo-5H-pyrido[2,3-b][1,4]benzodiazepin-11-yl)ethyl]piperazin-1-yl]butyl]carbamate
• CAS: 1136218-73-9
• 化学式: C₃₀H₃₄N₆O₄
• 分子量: 542.638
• InChiKey: CYNJHSQHXOLAEW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  40
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  107
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Method for Generating a Recombinant Clonal Cell Line and Novel Reagents for Use in the Method
  申请人：Hill Stephen John

  公开号：US20110300116A1

  公开（公告）日：2011-12-08

  A method for generating a recombinant clonal cell line expressing a target cell surface receptor at a specific level of expression from a cell population comprising cells transfected with a plasmid encoding the cDNA sequence of the target receptor and expressing the target cell surface receptor, the method comprising (c) incubating the cell population with a receptor specific fluorescent ligand (d) selecting single cells from step (c) expressing the target cell surface receptor by monitoring the specific binding of the fluorescent ligand using flow cytometry; and novel fluorescent ligands.

  一种用于从包含转染携带目标受体cDNA序列的质粒并表达目标细胞表面受体的细胞群体中生成表达特定水平目标细胞表面受体的重组克隆细胞系的方法，该方法包括：(c)将细胞群体与受体特异性荧光配体孵育；(d)通过使用流式细胞仪监测荧光配体的特异结合来选择步骤(c)中表达目标细胞表面受体的单个细胞；以及新型荧光配体。
• A METHOD FOR GENERATING A RECOMBINANT CLONAL CELL LINE AND NOVEL REAGENTS FOR USE IN THE METHOD
  申请人：Cellaura Technologies LTD

  公开号：EP2238248A2

  公开（公告）日：2010-10-13
• [EN] A METHOD FOR GENERATING A RECOMBINANT CLONAL CELL LINE AND NOVEL REAGENTS FOR USE IN THE METHOD<br/>[FR] MÉTHODE D'OBTENTION D'UNE LIGNÉE DE CELLULES CLONALES DE RECOMBINAISON ET NOUVEAUX RÉACTIFS UTILISÉS PAR LA MÉTHODE
  申请人：CELLAURA TECHNOLOGIES LTD

  公开号：WO2009040555A2

  公开（公告）日：2009-04-02

  A method for generating a recombinant clonal cell line expressing a target cell surface receptor at a specific level of expression from a cell population comprising cells transfected with a plasmid encoding the cDNA sequence of the target receptor and expressing the target cell surface receptor, the method comprising (c) incubating the cell population with a receptor specific fluorescent ligand (d) selecting single cells from step (c) expressing the target cell surface receptor by monitoring the specific binding of the fluorescent ligand using flow cytometry; and novel fluorescent ligands.