3-(5-Methoxy-1-methyl-1H-indol-3-ylmethyl)-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid amide | 622387-89-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-(5-Methoxy-1-methyl-1H-indol-3-ylmethyl)-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid amide
• 英文别名: 3-[(5-methoxy-1-methylindol-3-yl)methyl]-2-oxo-1,3-dihydroindole-5-sulfonamide
• CAS: 622387-89-7
• 化学式: C₁₉H₁₉N₃O₄S
• 分子量: 385.4
• InChiKey: YUFXVKVATYTTCX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  112
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• METHODS FOR TREATING HEMOLYTIC DISEASES AND SICKLE CELL DISEASE
  申请人：Turrini Francesco

  公开号：US20180078552A1

  公开（公告）日：2018-03-22

  The present disclosure generally relates to methods of treating hemolytic diseases such as sickle cell anemia using kinase inhibitors, for example, compounds that inhibit the spleen tyrosine kinase (SYK). In some embodiments a method is presented to prevent thrombosis in blood vessels of patients with a hemolytic disease comprising the step of: administrating to a patient having at least one hemolytic disease a therapeutically effective amount of at least one SYK inhibitor. In some embodiments the method includes repeatedly administering the SYK kinase inhibitor to a patient.
• SYK KINASE INHIBITORS AS TREATMENT FOR MALARIA
  申请人：PURDUE RESEARCH FOUNDATION

  公开号：US20200345737A1

  公开（公告）日：2020-11-05

  The disclosure relates to methods, compositions, and kits for treatment of parasite-mediated disease. In one embodiment, the disclosure relates to compounds, compositions, methods and kits for the treatment of malaria. In still another embodiment, the disclosure relates to a method for treating malaria comprising the use of a Syk kinase inhibitor.