N,N'-dicyclohexyl-O-acetylisourea | 79517-69-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,N'-dicyclohexyl-O-acetylisourea
• 英文别名: (N,N'-dicyclohexylcarbamimidoyl) acetate
• CAS: 79517-69-4
• 化学式: C₁₅H₂₆N₂O₂
• 分子量: 266.384
• InChiKey: YEVFUGIGVBEIQH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  50.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-hydroxy-1-(trimethylsilyl)ethyl 10-undecynoate 、 N,N'-dicyclohexyl-O-acetylisourea 在 4-二甲氨基吡啶 作用下， 以 乙醚 为溶剂， 反应 18.0h， 以91%的产率得到2-acetoxy-1-(trimethylsilyl)ethyl 10-undecynoate
  参考文献：
  名称：

  General synthesis of .omega.-acetylenic vinyl esters and ethers

  摘要：

  DOI：

  10.1021/jo00339a021
• 作为产物：
  描述：

  溶剂黄146 、 N,N'-二环己基碳二亚胺 在 4-二甲氨基吡啶 作用下， 以 乙醚 为溶剂， 生成 N,N'-dicyclohexyl-O-acetylisourea
  参考文献：
  名称：

  General synthesis of .omega.-acetylenic vinyl esters and ethers

  摘要：

  DOI：

  10.1021/jo00339a021

文献信息

• ALCOHOL OXIDASE-BASED ENZYME-LINKED IMMUNOSORBENT ASSAY
  申请人：Ippoliti Joseph Thomas

  公开号：US20080286812A1

  公开（公告）日：2008-11-20

  Disclosed is an assay for detecting an analyte. The method includes the steps of contacting a solution suspected of containing the analyte with capture antibodies specific for the analyte, wherein analyte contained in the solution is captured by the capture antibodies. Then contacting the capture antibodies with a solution containing the analyte attached to an alcohol oxidase (AOX) enzyme, to yield captured, labeled analyte. Then contacting the capture antibodies with a reagent mixture that generates a first signal proportional to the captured, labeled analyte and quantifying the first signal. And then measuring concentration of the analyte in the unknown sample by comparing the first signal to standard curve of signals. The assay can be implemented in an ELISA format.

  本发明涉及一种检测分析物的测定方法。该方法包括以下步骤：将疑似含有分析物的溶液与特异性捕获分析物的捕获抗体接触，其中溶液中的分析物被捕获抗体捕获。然后，将捕获抗体与连接有醇氧化酶（AOX）酶的分析物的溶液接触，以得到捕获的标记分析物。接着，将捕获抗体与产生与捕获的标记分析物成比例的第一信号的试剂混合物接触，并对第一信号进行定量测量。最后，通过将第一信号与信号标准曲线进行比较，测量未知样品中分析物的浓度。该测定方法可以在ELISA格式下实施。
• COMPOSITIONS AND METHODS FOR MODULATING APOLIPOPROTEIN C-III EXPRESSION
  申请人：Ionis Pharmaceuticals, Inc.

  公开号：EP3690049A1

  公开（公告）日：2020-08-05

  Provided herein are oligomeric compounds with conjugate groups targeting apoplipoprotein C-III (ApoCIII). In certain embodiments, the ApoCIII targeting oligomeric compounds are conjugated to N-Acetylgalactosamine. Also disclosed herein are conjugated oligomeric compounds targeting ApoCIII for use in decreasing ApoCIII to treat, prevent, or ameliorate diseases, disorders or conditions related to ApoCIII. Certain diseases, disorders or conditions related to ApoCIII include inflammatory, cardiovascular and/or metabolic diseases, disorders or conditions. The conjugated oligomeric compounds disclosed herein can be used to treat such diseases, disorders or conditions in an individual in need thereof.

  本文提供的是具有针对载脂蛋白 C-III（ApoCIII）的共轭基团的低聚化合物。在某些实施方案中，载脂蛋白 CIII 靶向低聚物化合物与 N-乙酰半乳糖胺共轭。本文还公开了用于减少载脂蛋白CIII以治疗、预防或改善与载脂蛋白CIII有关的疾病、失调或状况的靶向载脂蛋白CIII的共轭低聚物化合物。与载脂蛋白 CIII 有关的某些疾病、失调或病症包括炎症、心血管和/或代谢性疾病、失调或病症。本文公开的共轭低聚物化合物可用于治疗有需要的个体的此类疾病、失调或病症。
• Compounds and methods for treating cancer
  申请人：McTavish Hugh

  公开号：US20100216696A1

  公开（公告）日：2010-08-26

  The present invention provides a method of treating cancer involving administering an insulin-like growth factor-1 receptor (IGF-1 receptor) agonist and an anti-cancer chemotherapeutic agent. Also provided are compounds for treating cancer comprising an IGF-1-receptor ligand coupled to an anti-cancer chemotherapeutic agent. Also provided are compounds for treating cancer comprising an insulin-receptor ligand coupled to an anti-cancer chemotherapeutic agent.
• STEAROYL AMINO ACID SALT AND METHOD OF USE THEREOF
  申请人：Shanghai Jiaotong University School of Medicine

  公开号：US20180215703A1

  公开（公告）日：2018-08-02

  An isolated stearoyl amino acid salt of formula (II) or formula (III) is provided, wherein M in the formula (II) is K + , Na + , or NH 4 + ; and M 2+ in the formula (III) is Ba 2+ , Ca 2+ , or Mg 2+ . Also provided are compositions containing the isolated stearoyl amino acid salt and methods of using the isolated stearoyl amino acid salt and composition to treat a disorder, such as cerebral ischemia, stroke, Alzheimer's disease, and Parkinson's disease.
• US7811982B2
  申请人：——

  公开号：US7811982B2

  公开（公告）日：2010-10-12