Dihydro Astrophloxine | 1132970-43-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: Dihydro Astrophloxine
• 英文别名: (2E)-1-ethyl-2-[(E)-3-(1-ethyl-3,3-dimethyl-2H-indol-2-yl)prop-2-enylidene]-3,3-dimethylindole
• CAS: 1132970-43-4
• 化学式: C₂₇H₃₄N₂
• 分子量: 386.6
• InChiKey: LCCNORCLQFTDDF-KFTWTFIKSA-N

物化性质

• 熔点：
  41-43°C (dec.)
• 溶解度：
  可溶于二甲基亚砜、甲醇

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] APPLICATION OF REDUCED DYES IN IMAGING<br/>[FR] APPLICATION DE COLORANTS RÉDUITS EN IMAGERIE
  申请人：LI COR INC

  公开号：WO2013044156A1

  公开（公告）日：2013-03-28

  The present invention provides novel compounds and methods for hydrocyanines derived from near-infrared cyanine dyes, as reactive oxygen species probes in imaging. In certain embodiments, the present invention provides reduced dyes as substrates for ELISA and Western blots. In certain instances, the compounds are useful for detecting reactive oxygen species (ROS) probes for in vivo applications.

  本发明提供了从近红外青霉素染料衍生的新化合物和用于成像的氢氰染料的方法，作为反应性氧化物探针。在某些实施例中，本发明提供了作为ELISA和Western blots底物的还原染料。在某些情况下，这些化合物用于检测体内应用的反应性氧化物探针（ROS）。
• APPLICATION OF REDUCED DYES IN IMAGING
  申请人：LI-COR, INC.

  公开号：US20140213473A1

  公开（公告）日：2014-07-31

  The present invention provides novel compounds and methods for hydrocyanines derived from near-infrared cyanine dyes, as reactive oxygen species probes in imaging. In certain embodiments, the present invention provides reduced dyes as substrates for ELISA and Western blots.

  本发明提供了从近红外青菁染料衍生的新化合物和用于成像中作为反应性氧化物探针的方法。在某些实施例中，本发明提供了作为ELISA和Western blots底物的还原染料。
• REDUCED DYE PROBES FOR THE DETECTION OF RADICAL OXYGEN SPECIES
  申请人：Murthy Niren

  公开号：US20110070166A1

  公开（公告）日：2011-03-24

  Reduced dyes, such as hydrocyanines, deuterocyanines, and/or other deuterated dyes capable of detecting one or more reactive oxygen species are described herein. The reduced dyes exhibit little or no fluorescence due to the disrupted π conjugation. However, upon reaction with ROS, the reduced dyes are oxidized, regenerating the extended π conjugation and causing a substantial increase in fluorescence intensity. In many case, the oxidized dye is generally membrane impermeable. However, upon reduction, many of the reduced dyes are membrane permeable. Thus, reduced dyes can accumulate in cells and/or tissue to amplify the signal. Once inside the cell or tissue, the reduced dye is reoxidized upon reaction with ROS, and the oxidized dye again becomes membrane impermeable, trapping the dye within the cell. The reduced dyes can be used to image ROS, such as hydroxide radical and superoxide, in serum, cell cultures, tissue explants, and in vivo.
• US9470691B2
  申请人：——

  公开号：US9470691B2

  公开（公告）日：2016-10-18
• [EN] REDUCED DYE PROBES FOR THE DETECTION OF RADICAL OXYGEN SPECIES<br/>[FR] SONDES À COLORANT RÉDUIT POUR LA DÉTECTION D'ESPÈCES D'OXYGÈNE RADICALAIRES
  申请人：GEORGIA TECH RES INST

  公开号：WO2009121055A1

  公开（公告）日：2009-10-01

  Reduced dyes, such as hydrocyanines, deuterocyanines, and/or other deuterated dyes, such as deuteraled leuco dyes, capable of detecting one or more reactive oxygen species are described herein The reduced dyes are generally prepared by reducing the oxidized dye with a reducing agent, such as sodium borohydπde or sodium borodeuteride The reduced dyes exhibit little or no fluorescence due to the disrupted 1t conjugation However, upon reaction with ROS, the reduced dyes are oxidized, regenerating the extended 1r conjugation and causing a substantial increase in fluorescence intensity In many case, the oxidized dye starting material is generally membrane impermeable However, upon reduction, many of the reduced dyes are membrane pemieable Thus, reduced dyes can accumulate in cells and/or tissue Once inside the cell or tissue, the reduced dye is reoxidized upon reaction with ROS, and the oxidized dye again becomes membrane impermeable, trapping the dye within the cell.